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Record W4391810199 · doi:10.1016/j.medj.2024.01.005

Psilocybin-assisted psychotherapy for treatment resistant depression: A randomized clinical trial evaluating repeated doses of psilocybin

2024· article· en· W4391810199 on OpenAlexafffund
Joshua D. Rosenblat, Shakila Meshkat, Zoe Doyle, Erica Kaczmarek, Ryan M. Brudner, Kevin Kratiuk, Rodrigo B. Mansur, Christian Schulz, Rickinder Sethi, Shaun Ali, Jordan Bawks, Marc G. Blainey, Elisa Brietzke, Victoria Cronin, Jessica Danilewitz, Shalini Dhawan, Anthony Di Fonzo, M. Di Fonzo, Pawel Drzadzewski, William Dunlop, Hajnalka Fiszter, Fabiano A. Gomes, Smrita Grewal, Marisa Leon-Carlyle, Marilyn McCallum, Niki Mofidi, Hilary Offman, Jeremy Riva-Cambrin, Joel E. Schmidt, Mark E. Smolkin, Joan M. Quinn, Andrea Zumrova, Michelle Marlborough, Roger S. McIntyre

Bibliographic record

VenueMed · 2024
Typearticle
Languageen
FieldPsychology
TopicPsychedelics and Drug Studies
Canadian institutionsBrain and Cognition Discovery FoundationCanada Auto WorkersPublic Health OntarioKingston Health Sciences CentreMcMaster UniversityQueen's UniversityCanadian Transplant AssociationUniversity of Toronto
FundersSoutheastern Ontario Academic Medical OrganizationCanadian Institutes of Health ResearchPhysicians' Services Incorporated FoundationPaul Scherrer InstitutNational Natural Science Foundation of ChinaAbbVieUniversity of TorontoBrain and Behavior Research FoundationCanadian Cancer SocietyBrain and Cognition Discovery FoundationAbbVie CanadaBoehringer IngelheimMilken InstituteCanadian Psychiatric AssociationGlobal Alliance for Chronic Diseases
KeywordsPsilocybinTreatment-resistant depressionPsychotherapistRandomized controlled trialDepression (economics)PsychologyHallucinogenDepressive symptomsPsychiatryMedicineClinical psychologyMajor depressive disorderInternal medicineCognition

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.009
Threshold uncertainty score0.030

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.002
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0040.002
Bibliometrics0.0010.001
Science and technology studies0.0010.002
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0030.004
Insufficient payload (model declined to judge)0.0090.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.258
GPT teacher head0.544
Teacher spread0.286 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations93
Published2024
Admission routes2
Has abstractno

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