Self-Immolative Polymers: From Synthesis to Applications
Bibliographic record
Abstract
Polymers undergoing controlled degradation are of significant current interest. Among the classes of degradable polymers, self-immolative polymers (SIPs) are attracting increasing attention due to their ability to completely depolymerize from end to end following the cleavage of their endcap or backbone. Their amplified responses to stimuli, along with their ability to readily tune the stimulus to which they respond by changing only their endcap, are useful features for a variety of applications. This review covers the major classes of SIPs, including poly(benzyl carbamate)s, poly(benzyl ether)s, polyphthalaldehydes, polyglyoxylates, polydisulfides, polythioesters, and their related derivatives along with their endcaps. Distinctive features of their syntheses and depolymerizations are discussed. Applications of SIPs including imaging and sensing, therapeutics, gels, micro- and nanopatterning, transient or recyclable materials, and adhesives are described. We conclude with some challenges and future perspectives for the field.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.013 | 0.006 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".