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Record W4391990866 · doi:10.1055/s-0044-1779758

Dynamized Dilution of Ruta Graveolens Disrupts Plasma Membrane Organization and Decreases Migration of Melanoma Cancer Cells

2024· article· en· W4391990866 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueHomeopathy · 2024
Typearticle
Languageen
FieldChemistry
TopicSynthesis and Biological Evaluation
Canadian institutionsInstitut National de la Recherche Scientifique
Fundersnot available
KeywordsRuta graveolensDilutionCancerMembraneMelanomaChemistryTraditional medicineCancer researchMedicineBiochemistryInternal medicinePhysicsThermodynamics

Abstract

fetched live from OpenAlex

Background: Cell migration is a complex and heterogeneous process performed by all eukaryotic cell types. Defects in this mechanism could be associated with severe pathologies such as cancer. Cutaneous melanoma is a cancer with poor prognosis mainly because of metastatic dissemination and therefore a deregulation of cell migration. In recent years, preclinical publications studied the effect of homeopathic dilutions such as Ruta graveolens in tumoral cell lines and current therapies can benefit from homeopathy as supportive care in oncology. This study aimed to assess the effects of Ruta graveolens 9CH on plasma membrane reorganization and its influence on melanoma cell migration.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.018
Threshold uncertainty score0.742

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.240
Teacher spread0.229 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it