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Airway tree caliber heterogeneity and airflow obstruction among older adults

2024· article· en· W4392286449 on OpenAlexafffund
Motahareh Vameghestahbanati, Leina Kingdom, Eric A. Hoffman, Miranda Kirby, Norrina B. Allen, Elsa D. Angelini, Alain G. Bertoni, Qutayba Hamid, James C. Hogg, David R. Jacobs, Andrew F. Laine, François Maltais, Erin D. Michos, Coralynn Sack, Don D. Sin, Karol E. Watson, Artur Wysoczanksi, David Couper, Christopher B. Cooper, MeiLan K. Han, Prescott G. Woodruff, Wan C. Tan, Jean Bourbeau, R. Graham Barr, Benjamin M. Smith

Bibliographic record

VenueJournal of Applied Physiology · 2024
Typearticle
Languageen
FieldMedicine
TopicChronic Obstructive Pulmonary Disease (COPD) Research
Canadian institutionsSt. Paul's HospitalUniversité LavalUniversity of British ColumbiaToronto Metropolitan UniversityMcGill University
FundersNational Institute of Environmental Health SciencesCanadian Institutes of Health ResearchGovernment of CanadaCOPD FoundationNational Institute of Diabetes and Digestive and Kidney DiseasesNational Heart, Lung, and Blood InstituteAmerican Lung Association
KeywordsCaliberAirwayAirway obstructionAirflowMedicineCardiologyInternal medicineSurgeryHistory

Abstract

fetched live from OpenAlex

In this study, by leveraging two community-based samples and a case-control study of heavy smokers, we show that among older adults, airway tree caliber heterogeneity quantified by CT is associated with airflow obstruction and COPD independent of age, sex, height, race-ethnicity, and dysanapsis. These observations suggest that airway tree caliber heterogeneity is a structural trait associated with low baseline lung function and normal decline trajectory that is relevant to COPD.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.008

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.009
GPT teacher head0.269
Teacher spread0.260 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2024
Admission routes2
Has abstractyes

Explore more

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