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Record W4392390999 · doi:10.1093/ejcts/ezad415

European Association of Cardio-Thoracic Surgery (EACTS) expert consensus statement on perioperative myocardial infarction after cardiac surgery

2024· article· en· W4392390999 on OpenAlexafffund
Mario Gaudino, Marcus Flather, Davide Capodanno, Milan Milojevic, Deepak L. Bhatt, Giuseppe Biondi‐Zoccai, William E. Boden, P.J. Devereaux, Torsten Doenst, Michael E. Farkouh, Nicholas Freemantle, Stephen E. Fremes, John D. Puskas, Giovanni Landoni, Jennifer S. Lawton, Patrick O. Myers, Björn Redfors, Sigrid Sandner

Bibliographic record

VenueEuropean Journal of Cardio-Thoracic Surgery · 2024
Typearticle
Languageen
FieldMedicine
TopicCardiac, Anesthesia and Surgical Outcomes
Canadian institutionsHealth Sciences CentreSunnybrook Health Science CentreImpactUniversity of TorontoMcMaster UniversityPopulation Health Research Institute
FundersCanadian Institutes of Health ResearchEuropean Association for Cardio-Thoracic SurgeryMedical Research CouncilGedeon RichterAtriCureGaldermaAimmune TherapeuticsIpsenNovo NordiskNational Institute for Health and Care ResearchNational Institutes of HealthBoston Scientific CorporationSanofi
KeywordsMedicineCardiac surgeryMyocardial infarctionPerioperativeInternal medicineCardiologyCardiothoracic surgeryTroponinIntensive care medicineSurgery

Abstract

fetched live from OpenAlex

Cardiac surgery may lead to myocardial damage and release of cardiac biomarkers through various mechanisms such as cardiac manipulation, systemic inflammation, myocardial hypoxia, cardioplegic arrest and ischaemia caused by coronary or graft occlusion. Defining perioperative myocardial infarction (PMI) after cardiac surgery presents challenges, and the association between the current PMI definitions and postoperative outcomes remains uncertain. To address these challenges, the European Association of Cardio-Thoracic Surgery (EACTS) facilitated collaboration among a multidisciplinary group to evaluate the existing evidence on the mechanisms, diagnosis and prognostic implications of PMI after cardiac surgery. The review found that the postoperative troponin value thresholds associated with an increased risk of mortality are markedly higher than those proposed by all the current definitions of PMI. Additionally, it was found that large postoperative increases in cardiac biomarkers are prognostically relevant even in absence of additional supportive signs of ischaemia. A new algorithm for PMI detection after cardiac surgery was also proposed, and a consensus was reached within the group that establishing a prognostically relevant definition of PMI is critically needed in the cardiovascular field and that PMI should be included in the primary composite outcome of coronary intervention trials.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.044
metaresearch head score (Gemma)0.004
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.574
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0440.004
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0050.008
Bibliometrics0.0020.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.028
GPT teacher head0.296
Teacher spread0.269 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations40
Published2024
Admission routes2
Has abstractyes

Explore more

Same venueEuropean Journal of Cardio-Thoracic SurgerySame topicCardiac, Anesthesia and Surgical OutcomesFrench-language works237,207