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Record W4392466740 · doi:10.3389/fbrio.2024.1334712

Bacterial hypothetical proteins may be of functional interest

2024· article· en· W4392466740 on OpenAlexafffund
Antony T. Vincent

Bibliographic record

VenueFrontiers in Bacteriology · 2024
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenomics and Phylogenetic Studies
Canadian institutionsUniversité LavalMinistère de l'Agriculture, des Pêcheries et de l'Alimentation
FundersNatural Sciences and Engineering Research Council of Canada
KeywordsComputational biologyComputer scienceBiology

Abstract

fetched live from OpenAlex

Genomic analysis is part of the daily routine for many microbiology researchers. These analyses frequently unveil genes that encode proteins with uncertain functions, and for many bacterial species, these unknown genes constitute a significant proportion of their genomic coding sequences. Because these genes do not have defined functions, they are often overlooked in analyses. Experimentally determining the function of a gene can be challenging; however, ongoing advancements in bioinformatics tools, especially in protein structural analysis, are making it progressively easier to assign functions to hypothetical sequences. Leveraging various complementary tools and automated pipelines for annotating hypothetical sequences could ultimately enhance our comprehension of microbial functions and provide direction for new laboratory experiments.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.005
Threshold uncertainty score0.018

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0020.001
Insufficient payload (model declined to judge)0.0050.003

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.020
GPT teacher head0.233
Teacher spread0.213 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations21
Published2024
Admission routes2
Has abstractyes

Explore more

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