MétaCan
Menu
Back to cohort
Record W4392588676 · doi:10.1016/j.gimo.2024.101613

P709: Self reported vs genetic ancestry from the GENCOV COVID-19 genomic sequencing study

2024· article· en· W4392588676 on OpenAlexaffabout
Erika Frangione, Selina Casalino, Navneet Aujla, Radhika Mahajan, Lochana Jayachandran, Gregory Morgan, Mackenzie Scott, Juliet Young, Brendan C. Dickson, Saranya Arnoldo, Erin Bearss, Alexandra Binnie, Bjug Borgundvaag, Howard Chertkow, Marc Clausen, Marc Dagher, Luke Devine, Steven Friedman, Anne‐Claude Gingras, Lee Goneau, Deepanjali Kaushik, Zeeshan Khan, Elisa Lapadula, Georgia MacDonald, Tony Mazzulli, Allison McGeer, Shelley McLeod, Chloe Mighton, Trevor J. Pugh, David J. Richardson, Jared T. Simpson, Seth Stern, Lisa J. Strug, Ahmed Taher, Iris L. K. Wong, Natasha Zarei, Elena Greenfeld, Yvonne Bombard, Abdul Noor, Hanna Faghfoury, Jennifer Taher, Jordan Lerner‐Ellis

Bibliographic record

VenueGenetics in Medicine Open · 2024
Typearticle
Languageen
FieldMedicine
TopicSARS-CoV-2 and COVID-19 Research
Canadian institutionsHospital for Sick ChildrenOntario Institute for Cancer ResearchWomen's College HospitalUniversity Health NetworkUniversity of TorontoBaycrest HospitalWilliam Osler Health SystemLunenfeld-Tanenbaum Research Institute
Fundersnot available
KeywordsCoronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)BiologyGeneticsComputational biologyDNA sequencingVirologyMedicineGeneInternal medicineOutbreakInfectious disease (medical specialty)Disease

Abstract

fetched live from OpenAlex

The GENCOV study is a research initiative on ostensibly healthy COVID-19 positive adults in Toronto. Genomes for 1281 participants were sequenced and analyzed, and clinical characteristics were collected. GENCOV participants were surveyed on their self-reported ancestry. Race/ethnicity is known to have an impact on COVID-19 severity and susceptibility, as well as eligibility for genetic testing. However self-reported ancestry may not always accurately reflect individuals on a genetic scale if they are admixed with multiple ethnically distinct populations.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.052
Threshold uncertainty score0.103

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.004
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0010.000
Scholarly communication0.0010.000
Open science0.0000.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0040.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.195
GPT teacher head0.459
Teacher spread0.265 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes2
Has abstractyes

Explore more

Same venueGenetics in Medicine OpenSame topicSARS-CoV-2 and COVID-19 ResearchFrench-language works237,207