DeepMedFeature: An Accurate Feature Extraction and Drug-Drug Interaction Model for Clinical Text in Medical Informatics
Bibliographic record
Abstract
Drug-drug interactions (DDIs) are an important biological phenomenon which can result in medical errors from medical practitioners. Drug interactions can change the molecular structure of interacting agents which may prove to be fatal in the worst case. Finding drug interactions early in diagnosis can be pivotal in side-effect prevention. The growth of big data provides a rich source of information for clinical studies to investigate DDIs. We propose a hierarchical classification model which is double-pass in nature. The first pass predicts the occurrence of an interaction and then the second pass further predicts the type of interaction such as effect, advice, mechanism, and int. We applied different deep learning algorithms with Convolutional Bi-LSTM (ConvBLSTM) proving to be the best. The results show that pre-trained vector embeddings prove to be the most appropriate features. The F1-score of the ConvBLSTM algorithm turned out to be 96.39% and 98.37% in Russian and English language respectively which is greater than the state-of-the-art systems. According to the results, it can be concluded that adding a convolution layer before the bi-directional pass improves model performance in the automatic classification and extraction of drug interactions, using pre-trained vector embeddings such as Fasttext and Bio-Bert.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".