Loading Amlodipine on Diamond Nanoparticles: A Novel Drug Delivery System
Bibliographic record
Abstract
Shawqi H Alawdi,1,2 Housam Eidi,3 Marwa M Safar,4,5 Mosaad A Abdel-Wahhab6 1Department of Pharmacology, Faculty of Medicine and Health Sciences, Thamar University, Dhamar, Yemen; 2Department of Pharmacy Practice, Faculty of Pharmacy, University of Science and Technology, Sana’a, Yemen; 3Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, Canada; 4Pharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt; 5Pharmacology and Biochemistry Department, Faculty of Pharmacy, The British University in Egypt, El Shorouk, Egypt; 6Department of Food Toxicology and Contaminants, National Research Center, Cairo, EgyptCorrespondence: Shawqi H AlawdiDepartment of Pharmacology, Faculty of Medicine, Thamar University, Sana’a Street, Dhamar, YemenTel +967-777498977Email shawqialawdi@yahoo.comBackground: Diamond nanoparticles (Nanodiamond) are biocompatible drug delivery platforms with outstanding surface properties. Their passage into the brain has been confirmed previously. Thus, nanodiamond could provide a drug delivery system to shuttle several drugs through the blood-brain barrier (BBB) which represents a real challenge for the effective delivery of several drugs into the brain. Amlodipine is a calcium channel blocker that cannot pass through BBB and may elicit neuroprotective effects to reverse calcium-induced excitotoxicity and mitochondrial dysfunction that underlie several neurologic disorders including Alzheimer’s disease and stroke.Aim: The study aimed to investigate the loading of amlodipine on nanodiamond particles.Methods: Nanodiamond particles were oxidized in a strong oxidizing acidic mixture of sulfuric and nitric acids. Adsorption of amlodipine on nanodiamond particles was achieved in alkaline pH using various concentrations of sodium hydroxide. The loaded amlodipine was determined by high-performance liquid chromatography and confirmed by Fourier transform infrared (FTIR) spectroscopy and transmission electron microscopy.Results: The highest percentage (41%) of loaded amlodipine onto nanodiamond particles was achieved in alkaline medium using 2 mM NaOH at a corresponding pH of 8.5. Also, characteristic FTIR bands of amlodipine and nanodiamond were shown obviously in the nanodiamond–amlodipine conjugates. Moreover, the successful loading of amlodipine on diamond nanoparticles was confirmed by transmission electron microscopy.Conclusion: The present study demonstrates the successful loading of amlodipine onto nanodiamond particles. These findings offer a potential for applying diamond nanoparticles as a drug delivery system to shuttle amlodipine into the brain and open the door to deliver other similar drugs into the brain.Keywords: diamond nanoparticles, nanodiamond, amlodipine, calcium channel antagonists, drug delivery system, blood-brain barrier, excitotoxicity
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".