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Record W4392804637 · doi:10.1097/ccm.0000000000006207

Should Fludrocortisone be Added to Hydrocortisone in Septic Shock? Probably Yes, Based on Available Evidence*

2024· article· en· W4392804637 on OpenAlexaffabout
Nicholas A. Bosch, Tiago Pereira, Bijan Teja

Bibliographic record

VenueCritical Care Medicine · 2024
Typearticle
Languageen
FieldMedicine
TopicAdrenal Hormones and Disorders
Canadian institutionsUniversity of TorontoSt. Michael's Hospital
Fundersnot available
KeywordsFludrocortisoneMedicineSeptic shockHydrocortisoneShock (circulatory)Intensive care medicineSepsisInternal medicine

Abstract

fetched live from OpenAlex

1 The Pulmonary Center, Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA. 2 Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom. 3 Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada. 4 Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada. 5 Department of Anesthesia, St. Michael's Hospital, Toronto, ON, Canada. *See also p. e193. Dr. Bosch is supported by the National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute, the NIH/National Center for Advancing Translational Sciences, and the Department of Defense. Dr. Teja is supported by the Canadian Institutes of Health Research and by a Merit Award from the Department of Anesthesiology and Pain Medicine, University of Toronto. Dr. Pereira has disclosed that he does not have any potential conflicts of interest.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.003
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.717
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.003
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0040.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.079
GPT teacher head0.375
Teacher spread0.296 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes2
Has abstractyes

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