Abstract 2069 Analyzing the Impact of Co-Cultivation of Mesenchymal Stem Cells with H9c2 Cardiomyocytes on Cardiac Troponin-T Expression
Bibliographic record
Abstract
lack of phenotype as HCN2 WT, which indicates E457R preserved the CNB fold's autoinhibition.For the HCN4 TM substitution alone, an HCN2 R591E background exhibited the same positive VmDEACT-shift phenotype as an HCN2 WT background.This indicates that the open-state stabilization by HCN4 TM substitution works by a different mechanism than relief of CNB-mediated autoinhibition.But when HCN4 TM substitution was performed in HCN2 E457R R591E, the result was an even greater positive VmDEACT-shift, combined with a marked slowing of deactivation kinetics.Our findings uncover a key modulatory interaction between the C-linker and TM regions.When cAMP is bound, the potentiating mechanism involved in HCN4 TM substitution is vulnerable to disruption by introduction of Arg at in C-linker position 457.With no ligand, the C-linker is re-oriented so that Arg 457 now amplifies the potentiating mechanism involved in HCN4 TM substitution.Research supported
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".