Discrimination of Classical and Atypical BSE by a Distinct Immunohistochemical PrPSc Profile
Bibliographic record
Abstract
Bovine spongiform encephalopathy (BSE) is a fatal neurodegenerative disease in cattle belonging to the group of transmissible spongiform encephalopathies. Hallmark of the disease is the accumulation of the pathological prion protein (PrPSc) in the brain. Classical BSE (C-type) and two atypical BSE forms (L- and H-type) are known, and can be discriminated by biochemical characteristics. The data presented here underline that immunohistochemistry can also be used to identify type-specific PrPSc profiles which can be used for discriminatory purposes. For this brain samples from 21 cattle, intracerebrally inoculated with C-, H-, and L-type BSE, were used as well as three orally C-type BSE infected animals. Using six brain regions distinct lesion (H&E staining) and PrPSc profiles were determined. While the neuroanatomical distribution of lesions and the PrPSc accumulation were highly consistent between the groups, the topographic and cellular PrPSc profile revealed characteristic pattern for the different BSE types.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".