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Record W4393451774 · doi:10.5281/zenodo.6620796

MRI data for "Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the spreading, aggregation, and toxicity of α-synuclein in vivo"

2022· dataset· en· W4393451774 on OpenAlexaff
Rachel E. Lackie, Aline Silva de Miranda, Mei Peng Lim, Vladislav Novikov, Nimrod Madner, Nadun C. Karunatilleke, Benjamin S. Rutledge, Stéphanie Tullo, Anne Brickenden, Matthew E. R. Maitland, David Greenberg, Daniel Gallino, Wen Luo, Anoosha Ataram, Irina Shlafer, Esther del Cid‐Pellitero, Caroline Schild‐Poulter, Thomas M. Durcan, Edward A. Fon, Martin L. Duennwald, Flávio H. Beraldo, M. Mallar Chakravarty, Timothy J. Bussey, Lisa M. Saksida, Hermona Soreq, Wing‐Yiu Choy, Vânia F. Prado, Marco A. M. Prado

Bibliographic record

VenueZenodo (CERN European Organization for Nuclear Research) · 2022
Typedataset
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicEndoplasmic Reticulum Stress and Disease
Canadian institutionsMontreal Neurological Institute and HospitalDouglas CollegeMcGill UniversityWestern UniversityRobarts Clinical Trials
Fundersnot available
KeywordsPhosphoproteinIn vivoToxicityChemistryHop (telecommunications)Computational biologyBiologyBiochemistryPhosphorylationGeneticsComputer scienceComputer network

Abstract

fetched live from OpenAlex

Repository for magnetic resonance imaging data from the project titled "Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the spreading, aggregation, and toxicity of α-synuclein in vivo" Contains the pre-processed ex vivo T1-weighted images (Bruker 7T; 70 micron isotropic voxel resolution) for WT mice, M83 homozygous, and M83 homozygous mice with one copy of the TPR transgene. Full subject list can be viewed with the prado_MRI_M83dTPR_subjectlist_final.csv file. Whole brain region segmentations are available for these mice. These labels were generated using the MAGeT-Brain segementation pipleine (https://github.com/CobraLab/MAGeTbrain) and using a modified/merged version of the Allen brain atlas. The full list of regions included can be found in the file named Allen_brain_mapping_final.csv. See readme.txt file for more information

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Dataset · Consensus signal: Dataset
Teacher disagreement score0.102
Threshold uncertainty score0.342

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.004
Meta-epidemiology (narrow)0.0030.001
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0020.003
Science and technology studies0.0010.000
Scholarly communication0.0020.001
Open science0.0030.002
Research integrity0.0030.002
Insufficient payload (model declined to judge)0.1020.127

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.023
GPT teacher head0.253
Teacher spread0.231 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreDataset

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2022
Admission routes1
Has abstractyes

Explore more

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