Corticosteroid Hormone Glucocorticoids and Mineralocorticoid
Bibliographic record
Abstract
Glucocorticoids and mineralocorticoid are contributors to the corticosteroid hormone family, synthesized in the adrenal gland from the precursor sterol LDL cholesterol using the intermediate pregnenolone. Cortisol is an indispensable glucocorticoid in humans (in rodents, corticosterone), and aldosterone is an important mineralocorticoid. Cortisol and aldosterone share a time-honored synthesis pathway, are structurally similar, and exhibit a degree of cross-receptor affinity and function. Nevertheless, small variations in structure permit critical variants in physiological functions. Aldosterone classically acts via the mineralocorticoid receptor (MR) to promote sodium transport in the kidney and gut, thereby regulating long-term electrolyte homeostasis and blood stress control. Cortisol, via comparison, is well known for a sizeable range of metabolic and stress-related responses
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.005 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".