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Record W4394061717 · doi:10.1101/2024.04.04.588149

EMERGENCE OF OXA-48-LIKE CARBAPENEMASES IN CLINICAL ENTEROBACTERALES FROM GUATEMALA

2024· preprint· en· W4394061717 on OpenAlexaff
Carmen J. Mazariegos, Anna Quinto, Andres Herrera, Sara E. Barillas, Laura R. Valenzuela, Gabriela Ordóñez, Paola Sierra, Carolina Arévalo, Christine Seah, Roberto G. Melano

Bibliographic record

VenuebioRxiv (Cold Spring Harbor Laboratory) · 2024
Typepreprint
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicAntibiotic Resistance in Bacteria
Canadian institutionsPublic Health Ontario
Fundersnot available
KeywordsErtapenemKlebsiella pneumoniaeImipenemMicrobiologyBiologyPlasmidPiperacillinEscherichia coliPiperacillin/tazobactamGeneAntibiotic resistanceBacteriaGeneticsAntibioticsPseudomonas aeruginosa

Abstract

fetched live from OpenAlex

ABSTRACT Five isolates (four Klebsiella pneumoniae and one Escherichia coli ) displaying resistance to piperacillin/tazobactam and ertapenem and reduced susceptibility to imipenem were found positive for bla OXA-48 -like genes ( bla OXA-181 and bla OXA-232 ) carried on plasmids described previously. Although two K. pneumoniae recovered in 2020 were clonally related, the results suggest that bla OXA-48 -like genes have been circulating in Guatemala since 2019. This is the first report of this type of carbapenemase in Central America.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.058
Threshold uncertainty score0.115

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0010.000
Scholarly communication0.0010.000
Open science0.0000.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.017
GPT teacher head0.269
Teacher spread0.253 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes1
Has abstractyes

Explore more

Same venuebioRxiv (Cold Spring Harbor Laboratory)→Same topicAntibiotic Resistance in Bacteria→French-language works237,207→