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Record W4394268291 · doi:10.6084/m9.figshare.24186139

Additional file 2 of Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism

2023· dataset· en· W4394268291 on OpenAlexaff
Akihiro Yamashita, Olesia Ignatenko, Mai Thanh Thi Nguyen, Raphaëlle Lambert, Kathleen Watt, Caroline Daneault, Isabelle Robillard‐Frayne, Ivan Topisirović, Christine Des Rosiers, Heidi M. McBride

Bibliographic record

VenueOpen MIND · 2023
Typedataset
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicPeroxisome Proliferator-Activated Receptors
Canadian institutionsUniversité de MontréalMcGill UniversityMontreal Heart InstituteMontreal Neurological Institute and Hospital
Fundersnot available
KeywordsPeroxisomeFunction (biology)ChemistryCell functionCholesterolMetabolismDifferential (mechanical device)Cell biologyCellBiologyBiochemistryPhysicsReceptor

Abstract

fetched live from OpenAlex

Additional file 2. The file contains the following sheets, preceded with 'U2OS' or 'COS-7' : 1. counts_allgenes = raw read counts for all detected genes. 2. counts_analysedgenes = raw not normalised read counts for genes with at least 4 reads in at least 3 samples in the dataset. This gene list was used for differential expression analysis. 3. Deseq2 = differential expression analysis. 4. transformed reads_vsd or transformed reads_rlog = Deseq2 transformation of reads, used for generating heatmaps. 5. counts_normalised = Deseq2 normalisation of reads, used for generating scatter and others plots of indivual gene expression levels. 6. overlay sheets = overlay of COS-7 and U2OS datasets.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.010
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Dataset · Consensus signal: Dataset
Teacher disagreement score0.426
Threshold uncertainty score0.819

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.010
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0020.004
Science and technology studies0.0010.000
Scholarly communication0.0030.002
Open science0.0020.001
Research integrity0.0020.002
Insufficient payload (model declined to judge)0.4260.125

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.028
GPT teacher head0.286
Teacher spread0.259 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designNot applicable
Domainnot available
GenreDataset

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes1
Has abstractyes

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