MétaCan
Menu
← Back to cohort
Record W4394368873 · doi:10.6084/m9.figshare.12774915

Additional file 11 of The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation

2020· dataset· en· W4394368873 on OpenAlexaff
Adam Kosti, Patricia Rosa De Araujo, Weiqing Li, Gabriela D. A. Guardia, Jennifer Chiou, Caihong Yi, Debashish Ray, Fabiana Meliso, Yiming Li, Talia Delambre, Suzanne S. Burns, Franziska K. Lorbeer, Fanny Georgi, Markus Flosbach, Sarah Klinnert, Anne Jenseit, Xiufen Lei, Kevin Ha, Hong Zheng, Renu Pandey, Aleksandra Gruslova, Yogesh K. Gupta, Andrew Brenner, Erzsebet Kokovay, Timothy R. Hughes, Quaid Morris, Pedro A. F. Galante, Stefano Tiziani, Luiz O. F. Penalva

Bibliographic record

VenueFigshare · 2020
Typedataset
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCancer-related molecular mechanisms research
Canadian institutionsCanadian Institute for Advanced ResearchUniversity of Toronto
Fundersnot available
KeywordsGlioblastomaEpigeneticsBridging (networking)BiologyRNA-binding proteinCancer researchRNACancerGeneticsComputational biologyBioinformaticsGeneComputer science

Abstract

fetched live from OpenAlex

Additional file 11: Table S10. Gene set enrichment analysis (GSEA) of genes upregulated upon SERBP1 knockdown. Sheet 1, EZH2 and SUZ12 matches in ChEA 2016 datasets; sheet 2, EZH2 and SUZ12 matches in ENCODE 2015 datasets; sheet 3, genes with SUZ12 binding sites compared to upregulated set in SERBP1 knockdown; sheet 4, all genes with EZH2 binding sites compared to upregulated set in SERBP1 knockdown; sheet 5, H3K27me3 profile in embryonic stem cells; sheet 6, all genes with H3K27me3 sites compared to upregulated set in SERBP1 knockdown sheet 7; overlap all results: EZH2, SUZ12 and H3K27me3.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.008
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Dataset · Consensus signal: Dataset
Teacher disagreement score0.473
Threshold uncertainty score0.751

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.008
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0020.003
Science and technology studies0.0010.000
Scholarly communication0.0020.001
Open science0.0020.001
Research integrity0.0020.001
Insufficient payload (model declined to judge)0.4730.116

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.016
GPT teacher head0.256
Teacher spread0.240 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designNot applicable
Domainnot available
GenreDataset

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2020
Admission routes1
Has abstractyes

Explore more

Same venueFigshare→Same topicCancer-related molecular mechanisms research→French-language works237,207→