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Record W4394575809 · doi:10.1101/2024.04.04.588201

Multiple Dynamic Modes of the Bcd Gradient are Explained by Quantum Mechanics

2024· preprint· en· W4394575809 on OpenAlexaff
Irfan Lone, Carl Trindle

Bibliographic record

VenuebioRxiv (Cold Spring Harbor Laboratory) · 2024
Typepreprint
Languageen
FieldPhysics and Astronomy
TopicAtomic and Subatomic Physics Research
Canadian institutionsCanadian Quantum Research Center
Fundersnot available
KeywordsPhysicsClassical mechanicsMechanicsQuantum mechanicsStatistical physics

Abstract

fetched live from OpenAlex

Extracellular diffusion coupled with degradation is considered as the dominant mechanism behind the establishment of morphogen gradients. However, the fundamental nature of these biophysical processes visa viz the Bicoid (Bcd) morphogen gradient remains unclear. Fluorescence correlation spectroscopy (FCS) has recently revealed multiple modes of Bcd transport at different spatial and temporal locations across the embryo. We here show that these observations, and a few others, are fitted by a model fundamentally based on quantum mechanics. We also indicate that the abstract and auxiliary feature called chirality of the said formalism finds a natural expression in our model of the Bcd gradient formation that might be verified in future experiments on the system.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: Theoretical or conceptual
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.005

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0010.002
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.229
Teacher spread0.217 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes1
Has abstractyes

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