Effects of C-reactive protein and neutrophil to lymphocyte ratio on cognitive dysfunction after basal ganglia hemorrhage
Bibliographic record
Abstract
Abstract Objective To investigate the effects of C-reactive protein(CRP) and the neutrophils to lymphocytes ratio(NLR) on cognitive dysfunction after spontaneous basal ganglia hemorrhage. Methods 263 patients with spontaneous basal ganglia cerebral hemorrhage admitted to our hospital from September 2021 to January 2024 were selected as the study objects.Cognitive function was assessed by the Montreal Cognitive Assessment Scale (MoCA) after six months and divided into cognitive dysfunction group and normal cognitive function group.The level of CRP and NLR were compared between the two groups.The correlation between the level and degree of cognitive impairment was analyzed, and the correlation factors of cognitive impairment in spontaneous basal ganglia hemorrhage were studied by single factor, ROC curve and Logistic regression analysis. Results Among 263 patients, 120 (45.63%) had cognitive impairment after basal ganglia hemorrhage.The CRP and NLR in the cognitive dysfunction group were significantly higher than those in the normal cognitive function group (P < 0.05).ROC curve analysis showed that National Institute of Health Stroke Scale(NIHSS) score, amount of bleeding, white blood cells(WBC), absolute neutrophil count(ANC), NLR and CRP were associated with cognitive impairment after spontaneous basal ganglia hemorrhage.The area under the curve(AUC) of NLR was 83.1%, and the CRP was 77.4%.The NLR and CRP were the optimal predictive variables,The optimal prediction thresholds of ROC analysis were 3.88 and 3.34.Logistic regression analysis found that after adjusting for confounding factors, NLR and CRP were still independently associated with cognitive impairment after basal ganglia hemorrhage (OR = 1.38,95%CI: 1.15–1.64, P < 0.001) and (OR = 1.42,95%CI: 1.19–1.85, P < 0.001). Conclusion The NLR and CRP in the acute stage of spontaneous basal ganglia hemorrhage were independently associated with cognitive dysfunction after 6 months, suggesting that NLR and CRP may be the important biomarkers for predicting cognitive dysfunction after spontaneous basal ganglia hemorrhage.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".