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A randomized control trial investigating the effectiveness of a commercial pneumonia vaccine (Part II): Weaned lambs

2024· article· en· W4394681410 on OpenAlexaff
M.D. Gardner, J. Van Donkersgoed, C.A. Bauman, Maria Spinato

Bibliographic record

VenueSmall Ruminant Research · 2024
Typearticle
Languageen
FieldImmunology and Microbiology
TopicMicrobial infections and disease research
Canadian institutionsUniversity of Guelph
Fundersnot available
KeywordsVaccinationWeaningMedicinePneumoniaFeedlotBovine respiratory diseaseAnimal scienceRandomized controlled trialVaccine efficacyBiologyVeterinary medicineInternal medicineImmunology

Abstract

fetched live from OpenAlex

The objective of this randomized controlled vaccine field trial was to determine the effectiveness of a commercial respiratory bacterin, Ovipast™ Plus, administered to feedlot lambs at weaning, approximately 8 wk of age, to improve animal health, growth performance, and carcass traits. Lambs were weaned, weighed, and sorted into groups by sex and the previous Ovipast™ Plus vaccination status of their mother, because this is stage 2 of that ongoing trial (Gardner et al., 2023). Lambs born to vaccinated ewes were vaccinated with the Ovipast™ Plus bacterin and revaccinated 3 to 5 wk later. Lambs born to unvaccinated ewes were not vaccinated. During the growing and finishing phases of the trial, vaccination did not reduce pneumonia treatment rates, crude or pneumonia specific mortality rates, or improve growth rates. Vaccinated lambs had a lower carcass fat cover (P < 0.001) and a 1.33 times increased odds of yielding a Grade 1 carcass compared to unvaccinated lambs (P = 0.01). Vaccination reduced carcass fat cover and improved yield grades, but it had no beneficial effect on disease rates or growth performance, suggesting a limited economic benefit of vaccinating lambs post-weaning, which were borne from ewes vaccinated with Ovipast™ Plus during gestation.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.007
Threshold uncertainty score0.022

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.004
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0050.002
Bibliometrics0.0010.000
Science and technology studies0.0010.002
Scholarly communication0.0010.002
Open science0.0010.001
Research integrity0.0040.003
Insufficient payload (model declined to judge)0.0070.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.056
GPT teacher head0.354
Teacher spread0.298 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2024
Admission routes1
Has abstractno

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