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Efficacy of Butylphthalide Injection in Conjunction with Citicoline Sodium in Treating Ischemic Stroke

2024· article· en· W4394719646 on OpenAlexaboutno aff
Lin Kou, Juan Tan, Wenjie Yang, Xiaoyue Liu, Jing Zhou, Rong Liu

Bibliographic record

VenueIndian Journal of Pharmaceutical Sciences · 2024
Typearticle
Languageen
FieldNeuroscience
TopicNeurological Disease Mechanisms and Treatments
Canadian institutionsnot available
Fundersnot available
KeywordsCiticolineIschemic strokeConjunction (astronomy)MedicineStroke (engine)AnesthesiaInternal medicineIschemiaEngineeringAerospace engineeringPhysics

Abstract

fetched live from OpenAlex

To observe the clinical efficacy of butylphthalide injection in conjunction with citicoline sodium in treating ischemic stroke. From January 2022 to January 2023, our hospital admitted and randomly assigned 100 patients with acute ischemic stroke into two groups, control group and observation group. Each group consisted of 50 patients. Routine neurological treatment was administered to the control group, involving interventions such as fluid replacement, blood pressure control, lipid regulation, anticoagulation, correction of electrolyte imbalance, and intravenous infusion of butylphthalide injection. In addition to the standard treatment received by the control group, the observation group orally received citicoline sodium tablets. The assessment of therapeutic efficacy took place after duration of 2 w in both groups. Assessment of neurological injury repair was conducted using the national institutes of health stroke scale, while cognitive function recovery was evaluated through the implementation of the Montreal cognitive assessment scale. Utilizing computed tomography scan, cerebral blood volume and cerebral blood flow were quantified. The evaluation of activities of daily living was carried out employing the activities of daily living scale. Moreover, any adverse reactions occurring during the treatment period were duly documented. The occurrence of adverse reactions did not show a significant difference between the two groups, as reflected by a (p>0.05) that indicated no noteworthy disparity. When used in conjunction, butylphthalide injection and citicoline sodium exhibit a synergistic effect in treating ischemic stroke. This integrated treatment approach effectively promotes the repair of neurological injury and enhances cognitive function recovery. Furthermore, it improves cerebral blood flow perfusion and enhances daily life functionality, while maintaining a high level of safety.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.053
Threshold uncertainty score0.283

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.058
GPT teacher head0.356
Teacher spread0.298 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes1
Has abstractyes

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