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Record W4394721167 · doi:10.21203/rs.3.pex-2607/v1

A consensus platform for antibody characterization

2024· preprint· en· W4394721167 on OpenAlexafffund
Riham Ayoubi, Joël Ryan, Sara González Bolívar, Charles Alende, Vera Ruíz Moleón, Maryam Fotouhi, Kathleen Southern, Walaa Alshafie, Matt R. Baker, Alexander R. Ball, Danielle Callahan, Jeffery A Cooper, Katherine Crosby, Kevin J. Harvey, Douglas W. Houston, Ravindran Kumaran, Meghan A. Rego, Christine Schofield, Hai Wu, Michael Biddle, Claire M. Brown, Richard Kahn, Anita Bandrowski, Harvinder Virk, A.M. Edwards, Peter S. McPherson, Carl Laflamme

Bibliographic record

VenueResearch Square · 2024
Typepreprint
Languageen
FieldMedicine
TopicMonoclonal and Polyclonal Antibodies Research
Canadian institutionsMcGill UniversityUniversity of Toronto
FundersNational Institute on AgingGenentechMitacsMotor Neurone Disease AssociationOntario Genomics InstituteGovernment of CanadaEmory UniversityEuropean Federation of Pharmaceutical Industries and AssociationsMerck KGaABayerALS Society of CanadaOntario GenomicsGenome CanadaBristol-Myers SquibbSilicon Valley Community FoundationBill and Melinda Gates Foundation
KeywordsCharacterization (materials science)AntibodyComputer scienceComputational biologyBiologyNanotechnologyImmunologyMaterials science

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.022
metaresearch head score (Gemma)0.030
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Methods · Consensus signal: Methods
Teacher disagreement score0.047
Threshold uncertainty score0.157

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0220.030
Meta-epidemiology (narrow)0.0040.003
Meta-epidemiology (broad)0.0030.003
Bibliometrics0.0070.005
Science and technology studies0.0030.001
Scholarly communication0.0060.006
Open science0.0070.008
Research integrity0.0050.006
Insufficient payload (model declined to judge)0.0470.099

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.130
GPT teacher head0.479
Teacher spread0.349 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations12
Published2024
Admission routes2
Has abstractno

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