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A randomized control trial investigating the effectiveness of a commercial pneumonia vaccine (part I): Pre-weaned lambs

2024· article· en· W4394756924 on OpenAlexaff
M.D. Gardner, J. Van Donkersgoed, Maria Spinato, C.A. Bauman

Bibliographic record

VenueSmall Ruminant Research · 2024
Typearticle
Languageen
FieldImmunology and Microbiology
TopicMicrobial infections and disease research
Canadian institutionsCanadian Animal Health InstituteUniversity of Guelph
Fundersnot available
KeywordsPneumoniaRandomized controlled trialMedicineInternal medicine

Abstract

fetched live from OpenAlex

The objective of this controlled vaccine field trial was to determine the effectiveness of a commercial bacterin in increasing colostral immunity to reduce the risk of bacterial pneumonia in pre-weaned lambs in a commercial sheep operation. Pregnant ewes were randomly allocated to vaccination group (Ovipast™ Plus bacterin, n = 1807; unvaccinated, n = 1812). Ewe vaccination did not significantly (P > 0.05) improve lamb pneumonia treatment rates, crude or pneumonia specific mortality rates, or body weight gain . Interestingly, as birth weight increased in lambs from vaccinated ewes, they gained significantly more than lambs from unvaccinated ewes (P = 0.01). There was no difference in culture results from pneumonic lung samples for either Mannheimia haemolytica (P = 0.89) or Bibersteinia trehalosi (P = 1.00) between lambs from vaccinated and unvaccinated ewes. The results of this study suggest that there was no animal health and welfare benefit from vaccinating ewes with the Ovipast™ Plus bacterin prior to parturition to boost colostral immunity and improve health and growth in their lambs.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.021
metaresearch head score (Gemma)0.004
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.303
Threshold uncertainty score0.717

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0210.004
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0010.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.053
GPT teacher head0.359
Teacher spread0.306 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2024
Admission routes1
Has abstractyes

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