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Record W4394881056 · doi:10.56367/oag-042-11196

Building a sustainable, high-impact, and ‘living’ biobank infrastructure in Canada

2024· article· en· W4394881056 on OpenAlexaboutno aff
François Lamontagne, Paul C. Hébert, Michelle E. Kho

Bibliographic record

VenueOpen Access Government · 2024
Typearticle
Languageen
FieldMedicine
TopicEthics in Clinical Research
Canadian institutionsnot available
Fundersnot available
KeywordsBiobankMedicineBusinessMedical emergencyBioinformaticsBiology

Abstract

fetched live from OpenAlex

Building a sustainable, high-impact, and ‘living’ biobank infrastructure in Canada A living biobank can generate new insights about our care; Francois Lamontagne, Paul Hebert, and Michelle Kho tell us more. A detailed examination of diseased tissues and other biological specimens has enabled a better understanding of heart diseases, tumors, and syndromes such as sepsis. Biobanking involves collecting, storing, cataloguing and eventually analyzing these specimens. (1, 2) Specimens are most valuable when they are systematically linked to accurate clinical information (i.e. data), including risk factors, disease trajectories and ultimately, outcomes that are important to patients. This is no small feat and requires a lot of planning and infrastructure. One of the most important and difficult aspects is working with clinical teams and services to obtain access to patients and their medical records.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.006
metaresearch head score (Gemma)0.010
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.794
Threshold uncertainty score0.921

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0060.010
Meta-epidemiology (narrow)0.0000.001
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0020.003
Science and technology studies0.0200.006
Scholarly communication0.0090.003
Open science0.0030.007
Research integrity0.0020.004
Insufficient payload (model declined to judge)0.0130.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.128
GPT teacher head0.544
Teacher spread0.416 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations0
Published2024
Admission routes1
Has abstractyes

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