Abstract 16770: Aortic Stiffness is Negatively Associated With Physical Activity in Children With Congenital Heart Disease
Bibliographic record
Abstract
Introduction: Aortic stiffness is an important marker of cardiovascular risk and is increased in children with repaired congenital heart disease (CHD). We have observed and reported on this in children with Tetralogy of Fallot (TOF), Coarctation of the Aorta (CoA), Transposition of the Great Arteries (TGA) and Fontan circulation (FON). Physical activity (PA) is a key determinant of optimal vascular health in children. In children with CHD, we know little about the interaction between PA and aortic stiffness. Hypothesis: There is an inverse association between PA and aortic stiffness in children with TOF, CoA, TGA and FON. Methods: We recruited children aged 9-16 years old with TOF, CoA, TGA and FON during routine clinic visits. PA was objectively assessed using an ActiGraph accelerometer over the right hip during waking hours for 7 consecutive days. Daily minutes of moderate-to-vigorous PA and vigorous PA were averaged over at least 3 valid measurement days, using Evenson cut-points. We measured aortic pulse-wave-velocity (PWV) using standard echocardiographic technique. We calculated PWV (cm/s) by dividing the length of the aortic arch by the transit time from the ascending to descending aorta averaged across 6 consecutive cardiac cycles. Nonparametric statistical tests were used to compare aortic PWV and PA data (p<0.05). Results: Participants (n=68, 60% male) were 12.6 ± 2.3 years old (n=18 TOF, n=20 CoA, n=12 TGA, n=18 FON). Median daily moderate-to-vigorous PA was 45 (IQR: 34-64) minutes/day and vigorous PA was 11 (6-19) minutes/day. Median aortic PWV was 545 cm/s (409-710), which was significantly higher than for children without CHD (~360 cm/s, p<0.001). Lower aortic PWV values were related to higher levels of PA in terms of moderate-to-vigorous PA and vigorous PA (rho=-0.336, p=0.005 and rho=-0.323, p=0.007 respectively). Conclusions: In children with TOF, CoA, TGA and FON, higher levels of PA are associated with better vascular function as measured by aortic PWV. Aortic PWV is elevated in these groups compared to healthy children. The association between PA and vascular function in children with CHD supports the need for care providers to focus on routinely promoting PA in this at risk population.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".