A voxel-level approach to brain age prediction: A method to assess regional brain aging
Why this work is in the frame
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Bibliographic record
Abstract
Brain aging is a regional phenomenon, a facet that remains relatively under-explored within the realm of brain age prediction research using machine learning methods. Voxel-level predictions can provide localized brain age estimates that can provide granular insights into the regional aging processes. This is essential to understand the differences in aging trajectories in healthy versus diseased subjects. In this work, a deep learning-based multitask model is proposed for voxel-level brain age prediction from T1-weighted magnetic resonance images. The proposed model outperforms the models existing in the literature and yields valuable clinical insights when applied to both healthy and diseased populations. Regional analysis is performed on the voxel-level brain age predictions to understand aging trajectories of known anatomical regions in the brain and show that there exist disparities in regional aging trajectories of healthy subjects compared to ones with underlying neurological disorders such as Dementia and more specifically, Alzheimer’s disease. Our code is available at <a href='https://github.com/nehagianchandani/Voxel-level-brain-age-prediction'>https://github.com/nehagianchandani/Voxel-level-brain-age-prediction</a>
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.008 | 0.026 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it