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Record W4395449748 · doi:10.1073/pnas.2313971121

The potential importance of the built-environment microbiome and its impact on human health

2024· article· en· W4395449748 on OpenAlexafffund
Thomas C. G. Bosch, Mark Wigley, Beatriz Colomina, Brendan J. M. Bohannan, Forrest Meggers, Katherine R. Amato, Meghan B. Azad, Martin J. Blaser, Kate Brown, Maria Gloria Domínguez-Bello, S. Dusko Ehrlich, Eran Elinav, B. Brett Finlay, Kate Geddie, Naama Geva‐Zatorsky, Tamara Giles‐Vernick, Philippe Gros, Karen Guillemin, Louis‐Patrick Haraoui, Elizabeth L. Johnson, Frédéric Keck, Jamie Lorimer, Margaret McFall‐Ngai, Mark Nichter, Sven Pettersson, Hendrik N. Poinar, Tobias Rees, Carolina Tropini, Eduardo A. Undurraga, Liping Zhao, Melissa K. Melby

Bibliographic record

VenueProceedings of the National Academy of Sciences · 2024
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGut microbiota and health
Canadian institutionsMcMaster UniversityUniversité de SherbrookeMcGill UniversityCanada's Michael Smith Genome Sciences CentreChildren's Hospital Research Institute of ManitobaUniversity of ManitobaUniversity of British ColumbiaCanadian Institute for Advanced Research
FundersNational Institute of Environmental Health SciencesNational Institute of Allergy and Infectious DiseasesWissenschaftskolleg zu BerlinNational Institute of General Medical SciencesCanadian Institute for Advanced Research
KeywordsBuilt environmentMicrobiomeHuman healthDiversity (politics)Human microbiomeBiologyEcologyData scienceComputer scienceSociologyEnvironmental healthMedicineGenetics

Abstract

fetched live from OpenAlex

There is increasing evidence that interactions between microbes and their hosts not only play a role in determining health and disease but also in emotions, thought, and behavior. Built environments greatly influence microbiome exposures because of their built-in highly specific microbiomes coproduced with myriad metaorganisms including humans, pets, plants, rodents, and insects. Seemingly static built structures host complex ecologies of microorganisms that are only starting to be mapped. These microbial ecologies of built environments are directly and interdependently affected by social, spatial, and technological norms. Advances in technology have made these organisms visible and forced the scientific community and architects to rethink gene-environment and microbe interactions respectively. Thus, built environment design must consider the microbiome, and research involving host-microbiome interaction must consider the built-environment. This paradigm shift becomes increasingly important as evidence grows that contemporary built environments are steadily reducing the microbial diversity essential for human health, well-being, and resilience while accelerating the symptoms of human chronic diseases including environmental allergies, and other more life-altering diseases. New models of design are required to balance maximizing exposure to microbial diversity while minimizing exposure to human-associated diseases. Sustained trans-disciplinary research across time (evolutionary, historical, and generational) and space (cultural and geographical) is needed to develop experimental design protocols that address multigenerational multispecies health and health equity in built environments.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.008

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0010.002
Scholarly communication0.0020.001
Open science0.0000.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.027
GPT teacher head0.348
Teacher spread0.322 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations46
Published2024
Admission routes2
Has abstractyes

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