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Record W4395672315 · doi:10.5376/be.2024.14.0004

Advances in Animal Disease Resistance Research: Discoveries of Genetic Markers for Disease Resistance in Cattle through GWAS

2024· article· en· W4395672315 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

venuePublished in a venue whose home country is Canada.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueBiological Evidence · 2024
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicAnimal Genetics and Reproduction
Canadian institutionsnot available
Fundersnot available
KeywordsGenome-wide association studyDiseaseBiologyResistance (ecology)Plant disease resistanceGeneticsComputational biologyMedicineGenotypeSingle-nucleotide polymorphismPathologyGeneEcology

Abstract

fetched live from OpenAlex

This study summarizes the recent advancements in the application of GWAS technology in animal disease resistance research, emphasizing the importance and value of such studies. Initially, the genetic basis of animal disease resistance is introduced, with a focus on the relationship between the host immune system and disease resistance, as well as the genetic foundations of disease resistance. Subsequently, the principles, advantages, and historical development of GWAS technology in animal disease resistance research are elucidated. Following this, the application of GWAS technology in the discovery of genetic markers for disease resistance in cattle is discussed, including the research background, design methods, identified genetic markers for disease resistance, and their functional analysis. Finally, the significance of continued attention and support for animal disease resistance research is underscored, advocating for enhanced functional analysis of disease resistance-related genes, improved research data quality and sample sizes to advance animal disease resistance breeding.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.608
Threshold uncertainty score0.473

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.089
GPT teacher head0.380
Teacher spread0.291 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it