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Record W4395703205 · doi:10.1007/s10875-024-01704-x

Gérard Orth: From Viral to Human Genes Underlying Warts

2024· editorial· en· W4395703205 on OpenAlexaff
Jean‐Laurent Casanova, Emmanuelle Jouanguy

Bibliographic record

VenueJournal of Clinical Immunology · 2024
Typeeditorial
Languageen
FieldImmunology and Microbiology
TopicPoxvirus research and outbreaks
Canadian institutionsHospital for Sick Children
FundersAcadémie des Sciences, Institut de FranceInstitut Gustave-Roussy
KeywordsMedical microbiologyGeneBiologyVirologyGenetics

Abstract

fetched live from OpenAlex

Gérard Orth was born in 1936 and died in 2023.He was picky and prickly.He was sharp and scholarly.He was stern and serious.We loved him, even when he scolded us for forgetting a footnote to an abstract for a communication at a small workshop in a tiny town in the middle of nowhere in the 1960s.Detail was everything to him, but he was also unique in his global vision, which enabled him to make biological and medical breakthroughs in rabbits and humans, but also to discover both viral and host determinants of health and disease.At the time of his death, Gérard Orth was Emeritus Professor at the Institut Pasteur (where he worked from 1979 to 2003) and Emeritus Director of Research at the Centre National de la Recherche Scientifique (CNRS, between 1966 and 2001).He was elected to the French Veterinary Academy in 2003 and the French Academy of Sciences in 2004.Gérard worked at the Institut Gustave Roussy (IGR) in Villejuif from 1961 to 1979, initially in the "Laboratory of Biochemistry and Enzymology" of Claude Paoletti, and then, from 1975 onwards, in his own "Laboratory of Viral Etiologies of Human Cancers".François Gros eventually invited him to join the Institut Pasteur, where he founded and led the "Papillomavirus

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.005
metaresearch head score (Gemma)0.014
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Editorial · Consensus signal: Editorial
Teacher disagreement score0.010
Threshold uncertainty score0.026

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0050.014
Meta-epidemiology (narrow)0.0050.001
Meta-epidemiology (broad)0.0030.002
Bibliometrics0.0020.001
Science and technology studies0.0020.002
Scholarly communication0.0050.005
Open science0.0030.001
Research integrity0.0100.018
Insufficient payload (model declined to judge)0.0070.006

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.092
GPT teacher head0.440
Teacher spread0.348 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEditorial

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2024
Admission routes1
Has abstractyes

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