The Development and Performance of a Machine-Learning Based Mobile Platform for Visually Determining the Etiology of 5 Penile Diseases
Bibliographic record
Abstract
Objective: To develop a machine-learning visual classification algorithm for penile diseases in order to address disparities in access to sexual health services. Patients and Methods: We developed an image data set using original and augmented images for 5 penile diseases: herpes lesions, syphilitic chancres, balanitis, penile cancer, and genital warts. We used a U-Net architecture model for semantic pixel segmentation into background or subject image, an Inception-ResNet version 2 neural architecture to classify each pixel as diseased or nondiseased, and a salience map using GradCAM++. We trained the model on a random 91% sample of the images and evaluated the model on the remaining 9%, assessing recall (or sensitivity), precision, specificity, and F1-score. As of July 1st 2022, the model has been in use via a mobile application platform; we assessed application usage between July and October 1, 2023. Results: Of 239 images in the validation data set, 45 (18.8%) were of genital warts, 43 (18%) were of herpes simplex virus infection (ranging from early vesicles to ulcers), 29 (12.1%) were of penile cancer, 40 (16.7%) were of balanitis, 37 (15.5%) were of syphilitic chancres, and 45 (18.8%) were nondiseased images. The overall accuracy of the model for correctly classifying images was 0.944. There were 2640 unique submissions to the mobile platform; among a random sample (n=437), 271 (62%) were from the United States, 64 (14.6%) from Singapore, 41 (9.4%) from Canada, 40 (9.2%) from the United Kingdom, and 21 (4.8%) from Vietnam. Conclusion: We report on the development of a machine-learning model for classifying 5 penile diseases, which exhibited excellent performance.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".