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Record W4396576656 · doi:10.1002/alz.13836

The 2022 symposium on dementia and brain aging in low‐ and middle‐income countries: Highlights on research, diagnosis, care, and impact

2024· review· en· W4396576656 on OpenAlexaff
Raj N. Kalaria, Gladys E. Maestre, Simin Mahinrad, Daisy M Acosta, Rufus Akinyemi, Suvarna Alladi, Ricardo Allegri, Faheem Arshad, David Oluwasayo Babalola, Olusegun Baiyewu, Thomas H. Bak, Tarek Bellaj, David K. Brodie‐Mends, Marı́a C. Carrillo, Kaputu‐Kalala‐Malu Celestin, Albertino Damasceno, Ranil Karunamuni de Silva, Rohan de Silva, Mamuka Djibuti, Anna J. Dreyer, Ratnavalli Ellajosyula, Temitope Farombi, Robert P. Friedland, Noe Garza, Antoine Gbessemehlan, Eliza Georgiou, Ishtar Govia, Lea T. Grinberg, Maëlenn Guerchet, Seid Ali Gugssa, Joy Louise Gumikiriza‐Onoria, Eef Hogervorst, Michael Hornberger, Agustín Ibáñez, Masafumi Ihara, Thomas Gregor Issac, Linus Jönsson, Wambui Karanja, Joseph H. Lee, Iracema Leroi, Gill Livingston, Facundo Manes, Lingani Mbakile‐Mahlanza, Bruce L. Miller, Christine Musyimi, Victoria Mutiso, Noeline Nakasujja, David M. Ndetei, Sam Nightingale, Gabriela Novotni, Primrose Nyamayaro, Solomon Nyame, Julius A Ogeng’o, Adesola Ogunniyi, Maira Okada de Oliveira, Njideka Okubadejo, Martin Orrell, Stella‐Maria Paddick, Margaret A. Pericak‐Vance, Zvezdan Pirtošek, Felix Potocnik, Rema Raman, Mie Rizig, Mónica Rosselli, M. Salokhiddinov, Claudia L. Satizábal, Diego Sepúlveda‐Falla, Sudha Seshadri, Claire E. Sexton, Ingmar Skoog, Peter St George‐Hyslop, Cláudia Kimie Suemoto, Prekshy Thapa, Chinedu Udeh‐Momoh, Victor Valcour, Jeffery M. Vance, Mathew Varghese, Jaime H. Vera, Richard Walker, Henrik Zetterberg, Yared Z. Zewde, Ozama Ismail

Bibliographic record

VenueAlzheimer s & Dementia · 2024
Typereview
Languageen
FieldMedicine
TopicDementia and Cognitive Impairment Research
Canadian institutionsUniversity of TorontoCanada Research ChairsUniversity Health Network
FundersFogarty International CenterHORIZON EUROPE Framework ProgrammeDepartment of Communicative Sciences and Disorders, University of Wisconsin-MadisonGenentechNational Institutes of HealthNational Human Genome Research InstituteUK Dementia Research InstituteInternational Society for NeurochemistryAfrican Academy of SciencesVetenskapsrådetConselho Nacional de Desenvolvimento Científico e TecnológicoInstitut National de la Santé et de la Recherche MédicaleNational Research FoundationAXA Research FundWellcome TrustUniversity College LondonUniversity of SouthamptonNational Institute on AgingNational Institute for Health and Care ResearchUniversity of Sri JayewardenepuraAlzheimer's AssociationStiftelsen för Gamla TjänarinnorAromatic Plant Research CenterNewcastle UniversityGlobal Brain Health InstituteAgence Nationale de la RechercheAlzheimer's SocietyUniversity of Texas Rio Grande ValleyEU Joint Programme – Neurodegenerative Disease ResearchHjärnfondenEuropean CommissionFamiljen Erling-Perssons StiftelseUniversity of LouisvilleEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentAlzheimer's Drug Discovery FoundationNational Institute of Neurological Disorders and StrokeInternational Brain Research OrganizationNational Center for Advancing Translational SciencesIndian Council of Medical ResearchEconomic and Social Research CouncilU.S. Department of Health and Human ServicesNorthwestern UniversityU.S. Department of Defense
KeywordsDementiaGerontologyPsychologyMedicineInternal medicineDisease

Abstract

fetched live from OpenAlex

Two of every three persons living with dementia reside in low- and middle-income countries (LMICs). The projected increase in global dementia rates is expected to affect LMICs disproportionately. However, the majority of global dementia care costs occur in high-income countries (HICs), with dementia research predominantly focusing on HICs. This imbalance necessitates LMIC-focused research to ensure that characterization of dementia accurately reflects the involvement and specificities of diverse populations. Development of effective preventive, diagnostic, and therapeutic approaches for dementia in LMICs requires targeted, personalized, and harmonized efforts. Our article represents timely discussions at the 2022 Symposium on Dementia and Brain Aging in LMICs that identified the foremost opportunities to advance dementia research, differential diagnosis, use of neuropsychometric tools, awareness, and treatment options. We highlight key topics discussed at the meeting and provide future recommendations to foster a more equitable landscape for dementia prevention, diagnosis, care, policy, and management in LMICs. HIGHLIGHTS: Two-thirds of persons with dementia live in LMICs, yet research and costs are skewed toward HICs. LMICs expect dementia prevalence to more than double, accompanied by socioeconomic disparities. The 2022 Symposium on Dementia in LMICs addressed advances in research, diagnosis, prevention, and policy. The Nairobi Declaration urges global action to enhance dementia outcomes in LMICs.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.903
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.000
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0010.000
Open science0.0000.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.045
GPT teacher head0.389
Teacher spread0.344 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations84
Published2024
Admission routes1
Has abstractyes

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