34 DPP Lecture: Evidence of methionine effects on health and immune response of animals
Bibliographic record
Abstract
Abstract Methionine is an essential amino acid that is commonly supplemented in livestock diets, including for swine and poultry. As with other amino acids, requirements for methionine have largely been based on maximizing growth performance; however, there is evidence that nutrient requirements, including for sulfur amino acids, are altered by immune status of the animal. As such, there has been significant interest in exploring the non-proteinogenic functions of amino acids and how these work to support animal health in addition to growth performance. While methionine has a key role in protein synthesis, it is involved in numerous biological functions, including participation in transsulfuration and transmethylation pathways, as a precursor of intermediates in metabolic pathways (e.g., carnitine, cystine), and in components of the immune response (e.g., acute-phase proteins), and in antioxidant status (i.e. glutathione, taurine). While undersupply and oversupply of methionine can lead to deficiency and toxicity, respectively, it is likely that supplementation with methionine above the current recommendations for growth would be beneficial for animal health, especially during times of stress or immune stimulation.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.007 | 0.009 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".