A Prediction Equation for Incident CKD Using Routinely Collected Data: The Kidney Disease Risk Equation (KDRE)
Bibliographic record
Abstract
Background: The identification of individuals at risk for incident CKD (eGFR < 60 ml/min, stage 3a) is an important first step for disease surveillance, monitoring, education and allocation of key therapies to reduce CKD progression. Despite recommendations, albuminuria measurements in appropriate individuals remains poor. As such, we set out to develop and validate a prediction equation for new onset CKD with and without an albumin creatine ratio (ACR). Methods: Population-level administrative data cohort of 1,109,905 adults (>66 years old) from Ontario, Canada April 1, 2008 and December 31, 2017 with a minimum of 2 eGFR measures (one for baseline > 70 ml/min, one for outcome) were included. Prediction equations stratifying individuals with (n=191,690) and without (n=998,825) ACR were derived, internally validated by bootstrapping and externally validated in 122,144 (22,809 ACR, 99,335 non-ACR) individuals in Manitoba, Canada. The study outcome was a single eGFR measure < 60 mls/min/1.73 m2 with up to 10 years follow-up. In additional analyses, we examined two eGFR measures < 60 mls/min and a single eGFR < 45 ml/min as study outcomes. Results: Among individuals (54.5% women, mean age 64 SD 7, mean baseline eGFR 82 SD 8, median ACR 1 IQR 1-3), an eGFR < 60 ml/min occurred in 37.2% during the follow-up. The final model including up to 6 variables (age, sex, baseline eGFR, hemoglobin, time from hypertension and diabetes mellitus diagnosis) yielded a 5-year c-statistics of 0.77 (no ACR) and 0.78 (with ACR) with excellent calibration. Model performance was similar in additional analyses and in an external validation. Conclusions: An equation incorporating readily available and routinely collected administrative data variables can accurately predict the onset of CKD with or without ACR.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.005 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".