← Back to cohort
Tenecteplase versus standard of care for minor ischaemic stroke with proven occlusion (TEMPO-2): a randomised, open label, phase 3 superiority trial
Shelagh B. Coutts, Sandeep Ankolekar, Ramana Appireddy, Juan F. Arenillas, Zarina Assis, Peter Bailey, Philip A. Barber, Rodrigo Bazán, Brian Buck, Kenneth Butcher, Marie‐Christine Camden, Bruce Campbell, Leanne K. Casaubon, Luciana Catanese, Kausik Chatterjee, Philip Choi, Brian Clarke, Dar Dowlatshahi, Julia Ferrari, Thalia S. Field, Aravind Ganesh, Darshan Ghia, Mayank Goyal, Stefan Greisenegger, Omid Halse, MacKenzie Horn, Gary Hunter, Oje Imoukhuede, Peter J. Kelly, James Kennedy, Carol Kenney, Timothy Kleinig, Kailash Krishnan, Fabrício Oliveira Lima, Jennifer Mandzia, Martha Marko, Sheila Cristina Ouriques Martins, George Medvedev, Bijoy K. Menon, Sachin Mishra, Carlos A. Molina, Aimen Moussaddy, Keith W. Muir, Mark Parsons, Andrew M W Penn, Arthur Pille, Octávio Marques Pontes‐Neto, Christine Roffe, Joaquı́n Serena, Robert Simister, Nishita Singh, Neil J. Spratt, Daniel Strbian, Carol Huilian Tham, M Ivan Wiggam, David Williams, M Willmot, Teddy Y. Wu, Amy Yu, George Zachariah, Atif Zafar, Charlotte Zerna, Michael D. Hill, Marina Salluzzi, Nicole Blenkin, Ashley Dueck, Craig Doram, Qiao Zhang, Karla J. Ryckborst, Shelly Bohn, Quentin Collier, Frances Taylor, Brendan Cord Lethebe, Anitha Jambula, Kayla Sage, Lana Toussaint, Supryia Save, Jaclyn Lee, Nihay Laham-Karam, Asfia Sultan, A Sitaram, Andrew M. Demchuk, Andrew Lockey, Andrew Micielli, Ankur Wadhwa, Babawale Arabambi, B Graham, Chrysi Bogiatzi, Darshan Doshi, Debabrata Chakraborty, Diana Kim, Denise Vasquez, Dolly Singh, Dominic Tse, Earl C. Harrison, Eric E. Smith, Erika Teleg, Evgenia Klourfeld, Gary Klein, Ivy Sebastian, J. Grimley Evans, Janka Hegedus, Julie Kromm, Katie Lin, Katrina Hannah D. Ignacio, Kimia Ghavami, Mohd Pazudin Ismail, Margaret Moores, Marie-Andrée Panzini, Matthew Boyko, Mohammed Almekhlafi, Nancy Newcommon, Nicholar Maraj, Ondřej Volný, Peter K. Stys, Phillipe Couillard, Piyush Ojha, PrasannaVenkatesan Eswaradass, Raed A. Joundi, Ravinder Singh, R.M. Asuncion, Ryan T. Muir, Subhalaxmi Dey, Salman Mansoor, Sanchea Wasyliw, S Nagendra, Sherry Hu, Shorog Althubait, Shuo Chen, Simerpreet Bal, Stephen van Gaal, Steven Peters, Sucharita Ray, S. K. Chaturvedi, Suresh Subramaniam, Vivian Fu, Karina Villaluna, G. L. Maclean, Princess King-Azote, Chaoyang Ma, Alyson Plecash, Colleen Murphy, Laura Wilson, Oscar Benevente, P. Teal, Samuel Yip, Shivtaj Mann, B. Dewar, Michele Demetroff, Reham Shamloul, Rebeccah Beardshaw, Susan B. Roberts, Dylan Blaquiere, Grant Stotts, Michel Shamy, Olena Bereznyakova, Robert Fahed, Walid Alesefir, Suzy Lavoie, Annette Haché, Karine Collard, Ariane Mackey, Stéphanie Gosselin-Lefebvre, Steve Verreault, Brittany Beauchamp, Lindsay Lambourn, Alexander V. Khaw, Li Mai, Luciano A. Sposato, María Bres Bullrich, R. Azarpazhooh, Sebastián Fridman, Arunima Kapoor, Angela Southwell, Edoardo Bardi, Idris Fatakdawala, Maneesha Kamra, Kaitlynn M. Lopes, Najla Popel, Vanessa Norouzi, Aofeng Liu, Ann-Marie Liddy, Bismah Ghoari, Christine Hawkes, C.A. Enriquez, David J. Gladstone, Herbert Alejandro Manosalva Alzate, Houman Khosravani, Julia Hopyan, Kousik Sivakumar, Minnette T. Son, Mark I. Boulos, M.A. Hamind, Richard H. Swartz, Robert Murphy, Stephanie Reiter, Tony Fitzpatrick, V. Bhandari, J Good, Melanie Penn, Mary D. Naylor, Steven A. Frost, Arthur Cayley, Farhana Akthar, J. Williams, L Kalman, Lisa Crellin, Rebecca Wiegner, Ram Singh, Thomas G. Stewart, W. W. K. To, Sarman Singh, Aleksandra Pikula, Cheryl Jaigobin, Federico Carpani, Frank L. Silver, Helena Janssen, Joanna D. Schaafsma, Martín del Campo, Mohammed A. Alskaini, Phavalan Rajendram, Paige Fairall, Bonny Granfield, Dorothy H. Crawford, Juline Jabs, Laura White, Leka Sivakumar, Lori Piquette, Thanh N. Nguyen, Ali Zohair Nomani, Aaron Wagner, Anas Alrohimi, Anjum Rashid Butt, Alicia D’Souza, Bikram Prasad Gajurel, Chetan Vekhande, Hemant Kamble, Hayrapet Kalashyan, María Jesús Lloret, Mowad Benguzzi, Nazeem Arsalan, N. Ishaque, R. Ashayeriahmadabad, Robert Samiento, Saeed Hosseini, Stephanie Kazi, Saurav Das, T. Sugumar, D. Selchen, Pawel Kostyrko, Alexandra Muccilli, A.G. Saposnik, C. Vandervelde, Kanchana Ratnayake, S. McMillan, Aristeidis H. Katsanos, Ashkan Shoamanesh, Demetrios J. Sahlas, Vaman Naidoo, Vladimir Todorov, H Toma, Jaskiran Brar, Jungwha Lee, Mike Horton, Elaine Shand, Stuart Weatherby, A. Jin, Bryce A. Durafourt, Shirin Jalini, Aaron Gardner, Charlotte Tyson, Emily Junk, Kimberley Foster, Kala Bolt, Nicole J. Sylvain, S. Maley, Lilian Urroz, Lissa Peeling, Michael Kelly, R Whelan, R Cooley, Jeanne Teitelbaum, Alaae Boutayeb, Angela Moore, Edward Cole, Lloyd Waxman, Nadia Ben-Amor, R. Sanchez, Samah R. Khalil, Ahmad Nehme, Claudine Legault, Donatella Tampieri, Eric Ehrensperger, Lis Proença Vieira, M Cortes, Mark Angle, Mathew Hannouche, Mohamed Badawy, Klaus Werner, Sonja Wieszmuellner, A. Langer, Anna Gisold, Heidemarie Zach, Paulus Rommer, Susanne Macher, Stephan Blechinger, Wolfgang Marik, Wolfgang Series, M. Baumgartinger, Stefan Krebs, J. M. Koski, S. Eirola, Terhi Ivanoff, Anu Erakanto, Laura-Leena Kupari, Gerli Sibolt, Jorma Panula, Liisa Tomppo, Marjaana Tiainen, Matti Ahlström, N Martinez Majander, O Suomalainen, Silja Räty, Christopher Levi, E. Kerr, Jason W. Allen, Lara Kaauwai, Linda Belevski, Matthew Russell, Sally Ormond, Andrew Chew, Andre Loiselle, Angela Royan, Brett Hughes, Carlos García Esperón, Elizabeth Pepper, Ferdinand Miteff, Jiang He, Mitchell Lycett, Michelle S. Min, Nigel P Murray, Nils Pavey, R. Starling de Barros, Sidhu P. Gangadharan, S. Dunkerton, Stephen G. Waller, Tamara Canento Sánchez, Tom Wellings, Grant W. Edmonds, Karen Whittaker, Michael T. Ewing, Patricia Lee, Rowena Singkang, Amy McDonald, Alvani D. Santos, C. SHIN, David M. Jackson, Jessica Tsoleridis, Laura Fisicchia, N. Parsons, N. Shenoy, Albert V. Smith, Angelos Sharobeam, Anna Balabanski, A. Park, Cameron Williams, Davor Pavlin-Premri, Edrich Rodrigues, Fana Alemseged, Felix Ng, Hang Zhao, James Beharry, J.L. Ng, James D Williamson, J.Z.W. Wong, K. Li, Michael Kwan, Michael Valente, Nawaf Yassi, Vignan Yogendrakumar, B. McNamara, Claire Buchanan, Christine McCarthy, George Thomas, Krista Stephens, Min Young Chung, M.F. Chung, Michelle Tang, Tomislav Busch, Tanya Frost, Richard K. Lee, N J Stuart, Naila Pachani, A. Menon, Branko Borojevic, Chris Linton, Guillermo García, E.P. Callaly, HM Dewey, Jianjun Liu, Jingwen Chen, John Wong, Konrad Nowak, Karen To, Nathaniel Lizak, Oneil G. Bhalala, P. Park, Patricia Grace Chua Tan, Rui Martins, Robert Cody, Raeburn B Forbes, S.K. Chen, Sze‐Yuan Ooi, Shengxian Tu, Yuanchu Dang, Zhiyu Ling, Roy Drew, Aaron C. Tan, Craig Kurunawai, Jackson Harvey, Jeyaledchumy Mahadevan, Lavenia Cagi, Logesh Palanikumar, Linda Chia, Rou Xuan Goh, Shaddy El‐Masri, Berzenn Urbi, Catherine Rapier, Haylee Berrill, H C McEvoy, R. W. Dunning, Santhosh Kuriakose, Thomas Chad, V. Sapaen, Arman Sabet, Darshan Shah, David Gan Eng Yeow, Kathryn S. Lilley, Kathleen Ward, M Mozhy Mahizhnan, M. Tan, Christopher J. Lynch, Sam Coveney, Kenneth J. Tobin, John McCabe, Michael Marnane, Shelley L. Murphy, M. Large, Barry Moynihan, K. Boyle, Estela Sanjuán, Mireia Sanchis, Sandra Boned, Olalla Pancorbo, V. Sala, Luis I. García, Álvaro García‐Tornel, Jesús Juega, Jorge Pagola, K. Santana, Manuel Requena, Marián Muchada, Montse Olivé, Pardo Lozano, Marta Rubiera, Matías Deck, Noelia Rodríguez, B.A. Lavin Gomez, F J Reyes Munoz, Ángela Sánchez‐Algaba Gómez, AI Calleja Sanz, E Cortijo Garcia, G. Valle Peñacoba, María Elena Ramos, M. De Lera Alfonso, Anna Feliu, Laura Pardo, Paula Ramírez, Abel Murillo, D Lopez Dominguez, Jorge Rodríguez, Mikel Terceño Izaga, María Dolores Reina, Ursula Bojaryn, Victor Augusto Vera Monge, R. R Siew, Sherwin J. U. Agustin, Christopher Seet, A. d'Emden, Andrew J. Murray, Angela Welch, Kim Hatherley, Nicola C. Day, Wendy Smith, Ellen Macrae, Ed Mitchell, Ammad Mahmood, J. Elliot, S. Neilson, Viveka Biswas, Claire Brown, Adam Lewis, Amy Ashton, David J. Werring, Richard Perry, R. Muhammad, Y.C. Lee, AE Black, A. Robinson, Andrew Williams, A. Banaras, Cyrille Cahoy, Georgia Raingold, Mark Marinescu, Ndifreke Atang, Nathalie Bason, Nadia Francia, S Obarey, Shez Feerick, Jeffery Joseph, U Schulz, Robert Irons, John T. Benjamin, Linda Quinn, Monica Jhoots, Rachel Teal, Gary A. Ford, George Harston, H. Bains, Ivie Gbinigie, Philip Mathieson, Cheul-Muu Sim, Elizabeth Hayter, Kathleen A. Kennedy, Lauren Binnie, Naomi Priestley, Rhys Williams, Rita Ghatala, Samuel J. Stratton, Andrew R. Blight, Li Zhang, Andrew Davies, Helen Duffy, Jason D. Roberts, Jack Homer, Karen Roberts, K. Dodd, Kathryn Cawley, Carmen Martín, S Leason, Susan Cotgreave, Tracey Taylor, Arumugam Nallasivan, Shozeb Haider, Tia Chakraborty, Thomas J. Webster, Bryan Martin, B Joseph, Cindy Vargas Cabrera, David José, John Man, Jacqueline Del Carmen Aquino, S. Sebastian, Maria Österdahl, Michael Kwan, M Matthew, Noriyuki Ike, P Bello, Peter Wilding, Rodrigo Fuentes, Ruchir Shah, Sheila Mashate, Tarak Patel, U Nwanguma, Vivek Pravin Dave, A. Haber, A. Lee, Anthony O’Sullivan, Brendan Drumm, Angela Dawson, T. Matar, Dionne Roberts, Emma Taylor, Elisabeth Rounis, Abdel-Ghanny M El-Masry, Caitlin O'Hare, Dheeraj Kalladka, Selin Doğan Jamil, Jacques Auger, Oishik Raha, Michael D. Evans, Frederick W. Vonberg, Sadaf Kalam, Asim A. Sheikh, I. H. Jenkins, Jacob George, Joseph Kwan, Jelena Blagojević, M. A. Saeed, Michael Haji-Coll, Masaki Tsuda, M Sayed, Nicholas Winterkron, Narmathey Thanbirajah, Orsolya Vittay, R. Karim, Ruaridh Cameron Smail, Sumaiyyah Gauhar, Salwa Elmamoun, Susheel K. Malani, Shyam Kelavkar, Joanne Hiden, Peter Ferdinand, R. Sanyal, R. Varquez, Bryn M. Smith, Cassandra A. Okechukwu, Edward Fox, Emma Collins, Kathleen Courtney, Sudhir Tauro, Cynthia Patterson, Dennis J. McShane, Grant S. Roberts, Jim McIImoyle, K. McGuire, Patricia Fearon, P. Gordon, K Isaacs, Kayla V Lucas, Larissa L. Smith, Lucie Dews, M. Bates, S Lawrence, Susan Heeley, Vivek P. Patel, Y Chin, D. Sims, Edward Littleton, Jattinder Khaira, KarthickT Nadar, Agnieszka Kieliszkowska, B. Sari, Caroline Domingos Belo, Erika Manolo, J Aeron‐Thomas, Martina Doheny, Mónica Recamán, Maria Tibajia, Mohamed Aissa, Yee‐Haur Mah, Tao Yu, Salvadeeswaran Meenakshi‐Sundaram, S Heller, Rana Alnasser Alsukhni, Owain Williams, Mohamed Farag, Matthew Benger, Anish Engineer, Samantha Bayhonan, Sean Conway, Ajay Bhalla, Dimitrios Nouvakis, Evangelia Theochari, F. Boyle, James Teo, Josh King‐Robson, K.Y. Law, L. Sztriha, Andrew McGovern, D. Day, J. Mitchell-Douglas, Joseph Francis, Arshad Muhammad Iqbal, Puja Punjabivaryani, Javier Reyes, M Anonuevo Reyes, Mehrnoosh Pauls, Ashesh N. Buch, Aleksandra Hedström, Cary T. Hutchinson, C. Kirkland, James Newham, Gail M. Wilkes, Lora E. Fleming, N.A. Fleck, Anna Paula Botelho França, Bruna Cristine Chwal, Carolina Oldoni, Gabriel Paulo Mantovani, G Noll, Luca Zanella, Maurizio R. Soma, Thaís Secchi, Wyllians Vendramini Borelli, Brunna Rimoli, G. Silva, Leila Aparecida Machado Galvao Mondin, Riccardo Cerantola, Alexandre Kracker Imthon, Atsushi ESAKI, Millene Rodrigues Camilo, Otavio Costa Vincenzi, R.R. ds Cruz, Matheus Bernardon Morillos, Guilherme Gualberto Rodrigues, Kathleen Ferreira, Andréia Martini Pazini, Marjorie Ariele Pereira, Ana Leticia Amorim de Albuquerque, Carlos Massote Fontanini, C.F. Matinez Rubio, Davi Teixeira dos Santos, Flávia Aparecida Dias, F.F.A. Alves, C. Milani, Bruno Pegorer Santos, Fernanda Cristina Winckler, Jorge Teodoro de Souza, Luana Aparecido Muondo Bonome, V.A. Cury Silva, Robson Sarmento Teodoro, Gabriel Pinheiro Módolo, Natália Cristina Ferreira, Daniel Fabiano Barbosa dos Santos, Julio Cesar dos Santos Moreira, Alessandra Braga Cruz Guedes de Morais, J. Vieira, George Mendes, Joao Paulo de Queiroz
Bibliographic record
VenueThe Lancet · 2024
Typearticle
Languageen
FieldMedicine
TopicAcute Ischemic Stroke Management
Canadian institutionsSt. Michael's HospitalSunnybrook Health Science CentreAlberta Children's HospitalRed Deer Regional HospitalRoyal Columbian HospitalUniversity of SaskatchewanMcGill University Health CentreUniversity of OttawaPopulation Health Research InstituteWestern UniversityVictoria General HospitalMcMaster UniversityUniversity of TorontoOttawa HospitalUniversity of AlbertaUniversity Health NetworkUniversity of ManitobaHôpital de l'Enfant-JésusUniversity of British ColumbiaToronto Western HospitalQueen's UniversityMontreal Neurological Institute and HospitalFoothills Medical CentreHotchkiss Brain InstituteHealth Sciences CentreUniversity of Calgary
FundersCanadian Institutes of Health ResearchBritish Heart FoundationHeart and Stroke Foundation of Canada
KeywordsTenecteplaseMedicineThrombolysisIschaemic strokeStroke (engine)OcclusionPopulationFibrinolytic agentRandomized controlled trialInternal medicineCardiologyIschemiaTissue plasminogen activatorMyocardial infarction
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.165
Threshold uncertainty score0.446
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.046
GPT teacher head0.361
Teacher spread0.314 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations125
Published2024
Admission routes2
Has abstractno