Brachial Artery Flow-mediated Dilation Is Associated with Pulmonary Vascular Structure Among Patients with Chronic Obstructive Pulmonary Disease
Bibliographic record
Abstract
Background: Accumulating evidence indicates that pulmonary vascular insults, particularly at the level of the endothelium, may contribute to the pathogenesis of COPD. Further, the mechanism(s) underpinning pulmonary vascular remodeling/dysfunction in COPD may also contribute to systemic vascular dysfunction. Indeed, brachial artery flow-mediated dilation (FMD; an assessment of systemic vascular endothelial function) is inversely associated with emphysema among patients with COPD. However, it remains unclear whether systemic vascular function is related to pulmonary vascular structure in COPD. Thus, we aimed to evaluate the relationships between FMD and computed tomography (CT)-derived emphysema and pulmonary vascular structure in patients with mild-to-severe COPD. We hypothesized that FMD would be inversely related with CT-derived emphysema severity, and positively related with pulmonary vascular structure. Methods: 36 individuals with COPD (16 females, age: 69±6 years, FEV 1 : 62±19 % predicted ) completed three experimental days: Day 1: Enrollment and full pulmonary function test. Day 2: Chest CT scan to quantify emphysema severity (LAA-950), total vessel volume (TVV), and the volume of vessels with a cross sectional area of <5mm 2 (BV5) and between 5-10mm 2 (BV5-10). Day 3: Brachial artery FMD (5-minute forearm occlusion followed by 3-minute reactive hyperemia). FMD was allometrically scaled and corrected for the prevailing shear stimulus (shear rate area under the curve). Results: FMD was not correlated with LAA-950, (r 2 =0.09; P=0.09); however, positive relationships were observed between FMD and TVV normalized to total lung volume (r 2 =0.24; P<0.01), as well as BV5-10 (r 2 =0.34; P<0.01). FMD was not correlated to BV5 (r 2 =0.09, P=0.10). Conclusion: Collectively, these preliminary data indicate that, among patients with COPD, impaired pulmonary vascular structure is associated with attenuated systemic vascular function; suggesting an interplay between the pulmonary and systemic vasculature in the pathogenesis of COPD. Supported by the Canadian Institutes for Health Research, the Canadian Respiratory Research Network, and the “Fondation Baxter et Alma Ricard”. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".