Analysis of the Mechanism of Action of Trametinib: Extending the Lifespan of Female Fruit Flies in Intestinal Stem Cells
Bibliographic record
Abstract
“Trametinib ameliorates aging-associated gut pathology in Drosophila females by reducing Pol III activity in intestinal stem cells”, Proceedings of National Academy of Sciences of the United States of America, January 19, 2024, by Enric Ureña, Bowen Xu, Jennifer C. Regan, Linda Partridge and others from the University of Washington, Friday Harbor, Washington, Biotechnology and Biological Sciences Research Council. In this study, the team explored the potential of the anticancer drug Trametinib to extend lifespan and improve gut health in fruit flies. The results showed that Trametinib significantly extended the lifespan and improved the gut health of female Drosophila by inhibiting RNA polymerase III (Pol III) activity in intestinal stem cells (ISCs). In contrast, the drug had a weaker lifespan extension and no significant improvement in gut health in male Drosophila. The study also found that Trametinib exerts its life-extending effects in ISCs in part through a Maf1-mediated mechanism.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".