2024 NABIS Conference on Brain Injury Abstracts

Letter from ABI2024: Dear Colleagues, It is with great pleasure that we present the accepted scientific abstracts from the North American Brain Injury Society’s 17th Annual Conference on Brain Injury in this issue of the Journal of Head Trauma Rehabilitation. The conference was held in Las Vegas, Nevada March 27-30th, 2024. This year we were delighted to have received over 180 abstracts from investigators, clinicians, and researchers from around the world including some of the world’s leading clinical, academic, and research institutions. Moreover, we are proud of the high quality of research submitted and the broad range of relevant, interdisciplinary topics reflecting current advances being made across the continuum of care in the field of brain injury. For those of you who were unable to attend the NABIS 2024 meeting, we are pleased to present accepted scientific abstracts in the Journal of Head Trauma Rehabilitation (JHTR). In addition to the scientific oral and poster abstracts, NABIS- ABI 2024 had over 50 invited speakers presenting on the latest advances in ABI neuroscience and rehabilitation research. With the theme of “Evidence Informed Best Practices and Guidelines in Brain Injury Medicine and Neurorehabilitation”, the conference planning committee developed a dynamic educational program aimed at achieving optimal outcomes through interdisciplinary collaborations. Clinicians, researchers, administrators, and other brain injury professionals gathered during this four-day multi-track event which covered a variety of adult and pediatric brain injury topics including medical best practices, rehabilitation, research, community integration, life-long living, with advocacy and a knowledge translation emphasis. The conference program is posted on the NABIS website, www.abi2024.org. This past year, NABIS was also pleased to showcase six inspirational Pre-conference Courses. Pre-eminent leaders presented on Evidence Informed Management of Mild TBI’s, Assessment Tools for the Assessment and Management of Disorders of Consciousness: Novel Approaches for Motor Rehabilitation following ABI, and Pediatric Brain Injury: Best Practices to Enhance Clinical Care and Optimizing Outcomes. Finally, Brain Injury as a Chronic Health Condition and Training Emotional Recognition in Self and Others following ABI as half-day courses segued to the main conference. The main conference also featured leading experts presenting on essential ABI topics for every practicing clinician as well as researchers. Interactive sessions on Mild TBI, Disorders of Consciousness, Neuroplasticity, and Recovery Best Practices Rehabilitation were components of the broad-based program. Examples of practical education included but were not limited to headache evaluation management, pharmacologic rehabilitation, vision and vestibular current practices, neurologic music therapy and a context for applied complementary/alternative and integrative therapeutics. The educational offerings were rounded out with updated approaches to maximize community integration, lifelong living, and how best to manage ABI as a chronic condition to maximize one’s quality of life. Thank you for all your contributions toward making ABI 2024 a most successful educational, informational and networking event. We look forward to seeing you at future NABIS/IBIA/IPBIS meetings. We also thank you for your support of this multi-disciplinary dynamic organization and are hopeful for new membership growth in the upcoming year. We welcome your feedback on how this society can improve and meeting your society membership needs. Whether it is in research or clinical care, NABIS and IBIA stand behind the premise that advances in scientific research and translational clinical care will ultimately provide the best outcomes for those individuals and families affected by brain injuries as well as the community. Sincerely, Alan H. Weintraub, MD, FACRM, FAAPMR ABI 2024 Conference Chair Chair North American Brain Injury Society 10 Traumatic Brain Injury Induced Vision Impairment and Histone Methylation Rajaneesh Gupta1 1Banaras Hindu University, Varanasi, India Traumatic brain injury (TBI) is a major cause of mortality and morbidity in the world. TBI induces a chronic disease process causing visual loss which in turn affects day to day life of patients as well as their families. Understanding the underlying molecular mechanisms of TBI-induced vision impairment is a great challenge for neurobiologists, ophthalmologists, and other clinical practitioners. Our animal research study shows that TBI causes damage to the optic nerve and thinning of the retina culminating in compromised vision processing and perception. Axonal degeneration and demyelination in optic nerve and retinal ganglion cells (RGCs) loss in the retina is a crucial feature of vision impairment triggered by TBI. We have found that histone 3 dimethylation at lysine 9 residues (H3K9Me2) on antioxidants gene promoters like SOD can trigger oxidative stress in RGCs and oligodendrocyte precursor cells (OPCs) that was strongly correlated with retinal thinning, impairment of the retrograde transport of axons from visual cortex to neural retina, and demyelination of optic nerve following TBI. Our study suggests that epigenetic regulation of genes associated with oxidative stress could be a potential therapeutic target to restore visual deficits after TBI. 12 Strain-Rate Dependent Nature of Human Brain Tissue Under Shock Loading Mariusz Ziejewski1; Mohammed Hosseini Farid1; Mehran Fereydoonpour1; Ghodrat Karami1 1North Dakota State University, Fargo, United States In the realm of biomechanical analysis of brain tissue, the precise understanding of the material properties of intracranial head organs holds utmost significance in the exploration of head injury biomechanics. Research has revealed the substantial rate-dependent nature of these biological tissues, thereby emphasizing the necessity to ascertain their material properties within the spectrum of deformation rates they encounter. This paper employs a meticulously validated finite element model of the human head to delve into the biomechanics associated with impacts and blasts, both of which can result in traumatic brain injuries (TBIs). Our investigation encompasses simulations involving diverse impact directions and velocities. Additionally, we examine scenarios involving both helmeted and un-helmeted heads subjected to blast shock waves. Our study illuminates that brain strain rates range from 36 to 241 s-1, which is approximately 1.9 and 0.86 times the head acceleration observed during impact and blast scenarios, respectively. The skull, on the other hand, experiences strain rates spanning from 14 to 182 s-1, translating to roughly 0.7 and 0.43 times the head acceleration associated with impact and blast situations. Furthermore, the outcomes of our incident simulations unveil brainstem and dura mater strain rates within the ranges of 15 to 338 s-1 and 8 to 149 s-1, respectively. These findings not only contribute valuable insights into the characterization of brain tissue, cranial bone, brainstem, and dura mater, but also provide a foundational framework for the pre-selection of material properties in anticipation of computational dynamic studies concerning the human head and brain. 14 Is Virtual Service Delivery a Viable Way To Meet Clients’ Needs and Interests: A Needs Assessment of Virtual/Hybrid Day Programming for Clients With Acquired Brain Injury Sydney Rossiter1; Brooke Davis1 1University Of Ottawa, Ottawa, Canada Vista Centre Brain Injury Services (VCBIS) offer clients with acquired brain injury a day program of social leisure activities with the objective of connecting them with other clients and promoting skill development to encourage self-efficacy in their community. 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