Antimicrobial Assay of Metal Ions Using Yeast and Its Relevance to Food Preservation
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
The increasing occurrence of antimicrobial resistance in recent years has spurred research to produce new antimicrobial compounds. However, there is currently a lack of a rapid, simple, and quantitative assay to determine the antimicrobial characteristics of new antimicrobial compounds. In this study, we demonstrated that a simple water displacement apparatus can be used to determine the effects of various metal ions on the cell viability of a model organism Saccharomyces cerevisiae ( S. cerevisiae ) by monitoring the volume of CO 2 ( V CO 2 ) released. Analysis on the effect of different metal ions on S. cerevisiae demonstrated a linear relationship between V CO 2 and the reduction potentials and a linear–logarithmic relationship between V CO 2 and the metal/ligand binding constant indicating this measurement’s accuracy and quantitative nature. Due to its speed, simplicity, and accuracy, this water displacement method has the potential to be used as a pre-screening method to facilitate the rapid quantification and development of more effective antimicrobial agents for various applications including antimicrobial food preservation and packaging.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it