1663-P: The Impact of Time-Restricted Eating on Beta-Cell Function in Overweight Adults with Type 2 Diabetes—A Randomized Crossover trial
Bibliographic record
Abstract
Time-restricted eating (TRE) has been proposed as a non-pharmacological strategy with cardio-metabolic benefits in overweight individuals but little is known about its metabolic impact in type 2 diabetes (T2DM). Thus, we sought to evaluate whether TRE can improve beta-cell function and metabolic status in overweight individuals with early T2DM. In a cross-over randomized trial, 39 participants (25 women, age 56.3 yrs, BMI 32.4 kg/m2, T2DM duration 2.9 yrs, A1c 6.6%) were randomized to either 6-weeks of TRE (20h-fasting/4h-eating) or standard lifestyle, followed by 4-weeks washout before 6-weeks of the other approach to eating. The primary outcome of beta-cell function was assessed by Insulin Secretion-Sensitivity Index-2 (ISSI-2) derived from an oral glucose tolerance test. As compared to standard lifestyle, TRE induced a 14% increase in ISSI-2 (p=0.03) accompanied by 14% reduction of HOMA-IR (p=0.03) (Figure). Fasting glucose did not differ between interventions, but TRE yielded a significant reduction in A1c (-0.32%, p<0.001). These metabolic improvements were likely driven by its effects in reducing body weight by 3.86% (p<0.001) and waist circumference by 3.8 cm (p=0.003). In conclusion, TRE improved beta-cell function and insulin resistance in overweight patients with early T2DM, likely through its beneficial effects on adiposity. Disclosure C.K. Kramer: Research Support; Boehringer-Ingelheim. R. Retnakaran: Research Support; Boehringer-Ingelheim. Consultant; Eli Lilly and Company, Novo Nordisk, Sanofi. B. Zinman: Advisory Panel; Abbott, Eli Lilly and Company, Novo Nordisk. Funding Canadian Institutes of Health Research (PJT166091)
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".