Cronkhite-Canada Syndrome With Advanced Gastric Cancer
Bibliographic record
Abstract
CASE REPORT A 60-year-old man was diagnosed 11 years ago as having Cronkhite-Canada syndrome (CCS) based on multiple gastric polyps, diarrhea, hypoalbuminemia, and skin symptoms. There were multiple hamartomatous polyps in the colon but no polyps in the small intestine. After starting oral prednisolone (30 mg/day) 6 years ago, some polyps had reduced in size, but a protruding lesion of the gastric antrum tended to increase. Routine esophagogastroduodenoscopy showed a mixture of typical red caviar-like non-neoplastic polyps with edema and hyperemia and a protruding lesion with irregular surface pattern suspected of being a neoplasticity (Figures 1 and 2). Biopsy revealed irregular tubular structures suspicious for gastric cancer, so laparoscope-assisted distal gastrectomy was performed.Figure 1.: Esophagogastroduodenoscopy showed a mixture of typical red caviar-like non-neoplastic polyps and a lesion of suspected neoplasticity.Figure 2.: Narrow-band imaging clarified irregular surface-patterned lesion suggestive of neoplasticity.Surgical specimens showed a mixture of non-neoplastic tissue characterized by stromal edema and dilated glandular ducts and diverse neoplastic tissue such as tubular adenocarcinoma, signet-ring cell carcinoma, and adenoma (Figures 3 and 4). Chemotherapy was begun because the cancer had invaded the subserosa and metastasized to numerous lymph nodes. The patient died 1 year and 2 months after starting chemotherapy.Figure 3.: Surgical specimen with mixed non-neoplastic tissue and tubular adenocarcinoma (100× magnification).Figure 4.: Surgical specimen with mixed signet-ring cell carcinoma and adenoma (100× magnification).CCS is a rare gastrointestinal polyposis syndrome diagnosed on the basis of gastrointestinal symptoms such as chronic diarrhea and skin symptoms such as alopecia, onychodystrophy, and pigmentation. CCS requires caution because of complications of adenoma and carcinoma. In Japan, the gastric cancer complication rate for CCS is reported to be 10.2%.1 Durable polyp regression is associated with decreased cancer risk. Oral prednisolone at doses of 30 mg/day or more is appropriate for inducing clinical remission and regression of polyps.2 Endoscopic screening is also recommended at least once a year.1 The Helicobacter pylori antibody in this case was negative. The surgical specimens showed a mixture of non-neoplastic and neoplastic tissue, which strongly suggests that the cancer originated from a CCS polyp. Although this patient had advanced cancer, we believe this to be a valuable case in which preoperative observation with narrow-band imaging revealed the complication of neoplastic lesions. DISCLOSURES Author contributions: A. Goto: writing-original draft. S. Hashimoto: creating images. K. Yamamoto: creating images. J. Nishikawa: writing-original draft. T. Takami: supervision. A. Goto is the article guarantor. Financial disclosure: None to report. Previous presentation: Yamaguchi University Gastrointestinal Conference; November 29, 2023; Yamaguchi University Hospital. Informed consent was obtained for this case report.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.003 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.003 | 0.003 |
| Science and technology studies | 0.004 | 0.002 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.005 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".