Bibliographic record
Abstract
The yeast cell wall presents the first line of defense when interacting with external factors. In fungi, there are different responses to environmental stress, dependent both on the origin and magnitude of the stress. The response to stress in general, and more specifically membrane stress response has been outlined in many eukaryotes. However, the interaction of membrane-stress responses with mutagenesis and genome stability is unclear. Genome stability is maintained through cell division regulation. This is mediated by cell cycle signals, including the DNA replication checkpoint. In fission yeast, Schizosaccharomyces pombe, the cell integrity pathway activates a mitogenactivated protein kinase (MAPK) cascade. This particular pathway is defined by the kinase Pmk1. We find potential overlap between anti-fungal-induced membrane stress and the DNA replication checkpoint. Furthermore, we find that there is a Pmk1 dependent relationship between membrane stability and genome stability. Understanding the response to stress may allow for more efficient anti-fungal drug development.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".