Optical coherence tomography investigation on morphological phenotypes of Pannexin 1 in zebrafish eye
Bibliographic record
Abstract
This study investigates the relationship between Pannexin 1 and refractive errors using a custom-made 1310nm OCT system, capable of imaging the whole eye. Prior research reported vision-related issues in Panx1 mutants but lacked insights into underlying mechanisms. Obtained OCT results establish a direct link between Pannexin1 (Pannexin 1a, Pannexin 1b, and Panx1DKO) and eye structure alterations, primarily manifesting as axial length elongation and negative RRE values, indicating myopia. Additionally, whole eye OCT imaging identifies several category of defects in the lens epithelium and aphakia. This research underscores Pannexin1's significance in visual system development and refractive errors, further emphasizing the diagnostic potential of optical coherence tomography in ophthalmology. Leveraging zebrafish as a model organism offers a unique opportunity to investigate genetic and cellular mechanisms influencing eye health, advancing our understanding of genetic factors and paving the way for further research and potential therapeutic interventions in the field of ophthalmology.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".