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Record W4399886311 · doi:10.1038/s41597-024-03414-w

SARS-CoV-2 viral titer measurements in Ontario, Canada wastewaters throughout the COVID-19 pandemic

2024· article· en· W4399886311 on OpenAlexafffundabout
Patrick M. D’Aoust, Nada Hegazy, Nathan T. Ramsay, Minqing Ivy Yang, Hadi A. Dhiyebi, Elizabeth A. Edwards, Mark R. Servos, Gustavo Ybazeta, Marc Habash, Lawrence Goodridge, Art F. Y. Poon, Eric J. Arts, R. Stephen Brown, Sarah Jane Payne, Andrea E. Kirkwood, Denina Simmons, Jean‐Paul Desaulniers, Banu Örmeci, Christopher J. Kyle, David Bulir, Trevor C. Charles, R. Michael L. McKay, Kimberley Gilbride, Claire Oswald, Hui Peng, Vince Pileggi, Menglu L. Wang, Arthur Tong, Diego Orellano, Adebowale I. Adebiyi, Matthew Advani, Simininuoluwa O. Agboola, Dania Andino, Hussain Aqeel, Yash Badlani, Lena Carolin Bitter, Leslie M. Bragg, Julia Brasset-Gorny, Patrick Breadner, Stephen Brown, Ronny Chan, Babneet Channa, Jinjin Chen, Ryland Corchis-Scott, Matthew Cranney, Hoang Dang, Nora Danna, Rachel Dawe, Christopher T. DeGroot, Tomás de Melo, Justin Donovan, Walaa Eid, Isaac Ellmen, Joud Abu Farah, Farnaz Farahbakhsh, Meghan Fuzzen, Tim Garant, Qiudi Geng, Ashley Gedge, Alice Gere, Richard M. Gibson, Kimberly Gilbride, Eyerusalem Goitom, Qinyuan Gong, Tyson E. Graber, Amanda M. Hamilton, B. Haskell, Samina Hayat, Hannifer Ho, Yemurayi Hungwe, Heather Ikert, Golam Islam, D. Planer Joseph, Ismail Khan, Richard Kibbee, Jennifer J. Knapp, James Knockleby, Su-Hyun Kwon, Opeyemi U. Lawal, Line Lomheim, R. Menon, Élisabeth Mercier, Zach Miller, Aleksandra M. Mloszewska, Ataollah Mohammadiankia, Shiv Naik, Delaney Nash, Anthony Ng, Abayomi S. Olabode, Alyssa K. Overton, Gabriela Jimenez Pabon, Vinthiya Paramananthasivam, Jessica Pardy, Valeria R. Parreira, Lakshmi Pisharody, Samran Prasla, Melinda Precious, Fozia Rizvi, Matthew Santilli, Hooman Sarvi, Dan Siemon, Carly Sing-Judge, Nivetha Srikanthan, Sean Stephenson, Jianxian Sun, Endang Susilawati, Amir Tehrani, Ocean Thakali, Shen Wan, Martin Wellman, Katie Williams, Eli Zeeb, Elizabeth Renouf, Robert Delatolla

Bibliographic record

VenueScientific Data · 2024
Typearticle
Languageen
FieldMedicine
TopicSARS-CoV-2 detection and testing
Canadian institutionsChildren's Hospital of Eastern OntarioMinistry of the Environment, Conservation and ParksUniversity of WindsorTrent UniversityUniversity of GuelphOntario Tech UniversityMcMaster UniversityQueen's UniversityWestern UniversityUniversity of TorontoHealth Sciences NorthOttawa HospitalToronto Metropolitan UniversityCarleton UniversityUniversity of WaterlooUniversity of Ottawa
FundersMinistère de l’Environnement, de la Protection de la nature et des ParcsCanadian Institutes of Health ResearchUniversity of WaterlooUniversity of TorontoUniversity of Ontario Institute of TechnologyTrent UniversityQueen's UniversityMcMaster UniversityUniversity of WindsorUniversity of Ottawa
KeywordsPandemicCoronavirus disease 2019 (COVID-19)VirologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakTiterBetacoronavirusBiologyMedicineVirusOutbreakInfectious disease (medical specialty)

Abstract

fetched live from OpenAlex

During the COVID-19 pandemic, the Province of Ontario, Canada, launched a wastewater surveillance program to monitor SARS-CoV-2, inspired by the early work and successful forecasts of COVID-19 waves in the city of Ottawa, Ontario. This manuscript presents a dataset from January 1, 2021, to March 31, 2023, with RT-qPCR results for SARS-CoV-2 genes and PMMoV from 107 sites across all 34 public health units in Ontario, covering 72% of the province's and 26.2% of Canada's population. Sampling occurred 2-7 times weekly, including geographical coordinates, serviced populations, physico-chemical water characteristics, and flowrates. In doing so, this manuscript ensures data availability and metadata preservation to support future research and epidemic preparedness through detailed analyses and modeling. The dataset has been crucial for public health in tracking disease locally, especially with the rise of the Omicron variant and the decline in clinical testing, highlighting wastewater-based surveillance's role in estimating disease incidence in Ontario.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.032
Threshold uncertainty score0.230

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.004
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0020.006
Science and technology studies0.0020.001
Scholarly communication0.0010.000
Open science0.0010.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.274
GPT teacher head0.386
Teacher spread0.112 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations15
Published2024
Admission routes3
Has abstractyes

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