Dose-Dependent Toxicological and Histological Effects of Chloramphenicol in Nude Mice
Bibliographic record
Abstract
Chloramphenicol is a widely used broad-spectrum antibiotic in both human and veterinary medicine.Although it is successful in treating a number of bacterial diseases, concerns have been raised about its negative effects.To examine the toxicological and histological consequences of chloramphenicol in vivo, this study used a naked mouse model.After chloramphenicol injection, the health of the cells was assessed using histological examinations of the liver, kidney, and heart tissues.The cell viability of the liver, kidney, and heart tissues decreased by 39.02%, 43.04%, and 36.25%,respectively, at the highest dose (100mg/kg body weight).The liver, kidneys, and heart, respectively, each had an average damage score of 3.5, 4.0, and 3.6 at the maximum dosage, according to histological findings, which indicated serious organ damage.Because of the kidney's role in excreting drugs, the toxic effects seen were notably more pronounced in this organ.These findings highlight the potential risks of using chloramphenicol, particularly at high dosages, and the need for more research to understand the mechanisms underlying chloramphenicol-induced toxicity.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".