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Record W4400002808 · doi:10.21203/rs.3.rs-4150225/v1

Brain clocks capture diversity and disparity in aging and dementia

2024· preprint· en· W4400002808 on OpenAlexaff
Agustín Ibáñez, Sebastián Moguilner, Sandra Baez, Hernán Hernandez, Joaquín Migeot, Agustina Legaz, Raúl González-Gómez, Francesca R Farina, Pavel Prado, Jhosmary Cuadros, Enzo Tagliazucchi, Florencia Altschuler, Marcelo Adrián Maito, Maria Eugenia Godoy, Josephine Cruzat, Pedro A. Valdés‐Sosa, Francisco Lopera, John Fredy Ochoa-Gómez, Alfredis González‐Hernández, Jasmin Bonilla‐Santos, Rodrigo A. Gonzalez‐Montealegre, Renato Anghinah, Luís d'Almeida Manfrinati, Sol Fittipaldi, Vicente Medel, Daniela Olivares, Görsev Yener, Javier Escudero, Claudio Babiloni, Robert Whelan, Bahar Güntekin, Harun Yırıkoğulları, Hernando Santamaría‐García, Alberto Fernández, David Huepe, Gaetano Di Caterina, Marcio Soto‐Añari, Agustina Birba, Agustín Sainz‐Ballesteros, Carlos Coronel‐Oliveros, Amanuel Yigezu, Eduar Herrera, Daniel Abásolo, Kerry Kilborn, Nicolás Rubido, Ruaridh Clark, Rubén Herzog, Deniz Yerlikaya, Kun Hu, Mario A. Parra, Pablo Reyes, Adolfo M. García, Diana Matallana, José Alberto Ávila‐Funes, Andrea Slachevsky, María Isabel Behrens, Nilton Custodio, Juan F. Cardona, Pablo Barttfeld, Ignacio Brusco, Martín A. Bruno, Ana Sosa Ortiz, Stefanie Danielle Piña‐Escudero, Leonel Tadao Takada, Elisa de Paula França Resende, Katherine L. Possin, Maira Okada de Oliveira, Alejandro López Valdés, Brian Lawlor, Ian H. Robertson, Kenneth S. Kosik, Claudia Duran‐Aniotz, Victor Valcour, Jennifer S. Yokoyama, Bruce L. Miller

Bibliographic record

VenueResearch Square · 2024
Typepreprint
Languageen
FieldNeuroscience
TopicFunctional Brain Connectivity Studies
Canadian institutionsTrinity College
FundersFondo de Financiamiento de Centros de Investigación en Áreas PrioritariasFogarty International CenterDepartamento de Investigaciones Científicas y Tecnológicas, Universidad de Santiago de ChileAgencia Nacional de Investigación y DesarrolloUniversidad de Santiago de ChileNational Institutes of HealthAlzheimer's Association
KeywordsDementiaSocioeconomic statusAudiologyBrain activity and meditationCognitionElectroencephalographyNeuroimagingFunctional magnetic resonance imagingPsychologyDiseaseMedicineNeuroscienceEnvironmental healthInternal medicinePopulation

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.008
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.010

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.008
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.093
GPT teacher head0.368
Teacher spread0.275 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2024
Admission routes1
Has abstractno

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