Yeast-Derived Beta-Glucan Supplementation on Antibody Response Following Influenza Vaccination: A Protocol for a Randomized, Placebo-Controlled Study (M-Unity)
Bibliographic record
Abstract
vasculature and structure to establish early modifiable biomarkers of age-related cognitive decline.Methods: Adults 60y, 20 cognitively healthy and 20 with cognitive impairment, will be recruited.Peripheral microvascular abnormalities will be quantified in real-time using computer-assisted intravital microscopy, a novel noninvasive technology.Additionally, plasma levels of Hcy and its determinants (folate, B12, B6, creatinine) will be measured.Microvascular abnormalities and the plasma analytes will be compared to cerebral vasculature and structure (subcortical infarcts, lacunes, white matter hyperintensities, enlarged perivascular spaces, cerebral microbleeds, cerebral perfusion, and total and regional brain volumes) using magnetic resonance imaging.Results: N/A.Conclusions: This study will elucidate the relationships among peripheral microvascular abnormalities, Hcy, and cerebral vasculature and structure in older adults paving the way for targeted interventions to modify these biomarkers (e.g., B vitamin supplementation) and potentially prevent or slow disease progression.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".