Biofortified Orange-Fleshed Sweetpotato Can Meaningfully Reduce the Burden of Vitamin A Deficiency
Bibliographic record
Abstract
Objectives: Polyunsaturated fatty acids (PUFA) have been shown to have potential health benefits in chronic inflammatory diseases such as atherosclerosis, fatty liver, and various gastrointestinal disorders.However, PUFA are also prone to oxidation, leading to the formation of harmful by-products, including reactive carbonyl compounds (RCCs), which may disrupt gastrointestinal homeostasis.This study aims to investigate the impact of PUFA intake on adults with gastrointestinal symptoms.Methods: This cross-sectional study utilized the National Health and Nutrition Examination Survey (NHANES) dataset from 2007 to 2016.PUFA intake from foods and supplements was estimated from two non-consecutive 24-hour diet recalls.The study assessed the association between PUFA intake and gastrointestinal conditions involving vomiting or diarrhea within 30 days, while controlling for various covariates including age, gender, race, education level, body mass index, Family PIR, diabetes, hypertension, and alcohol consumption.Participants with missing or invalid data were excluded from the analysis.The data was analyzed using weighted linear regression tests and univariate and multivariate weighted logistic regression models, with participants divided into quartiles based on PUFA intake.Results: This study included 10,027 individuals, among whom 852 reported gastrointestinal symptoms and 9,175 were asymptomatic.The weighted linear regression test indicated a significant association between PUFA intake and gastrointestinal symptoms (p < 0.05).Univariate logistic regression analysis revealed higher odds of gastrointestinal symptoms with increased PUFA intake from foods(OR: 0.936, 95%CI: 0.879 -0.997, P ¼0.041).The highest quartile of PUFA was associated with a greater proportion of individuals experiencing gastrointestinal symptoms compared to the lowest quartile.Subgroup nalyses indicated a stronger association between polyunsaturated fatty acid intake and the risk of gastrointestinal symptoms in the highest quartile among women.Conclusions: Higher intake of PUFA was found to be positively associated with an increased risk of developing gastrointestinal symptoms.The observed associations are biologically plausible, and further validation through large-scale prospective studies is warranted.These findings have potential implications for physicians to consider dietary modifications as part of patient treatment, and for affected individuals to adjust their dietary habits to alleviate gastrointestinal symptoms.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".