P279 Patients with small-bowel vascular lesions report worse quality-of-life and fatigue scores than those with anaemia unrelated to small bowel disease
Why this work is in the frame
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Bibliographic record
Abstract
<h3>Introduction</h3> Chronic anaemia associated fatigue & limitations to activity can have significant negative impacts on QoL. The diagnosis of SB vascular lesions including sporadic angiodysplasia is often delayed and current management options are limited & frequently suboptimal. The specific impact of SB vascular lesions on QoL should be assessed and represents a target for future therapies. <h3>Methods</h3> Patients referred for capsule endoscopy(SBCE) with anaemia and negative OGD & Colonoscopy were invited to complete a RAND 36-Item Health Survey(SF-36) & Fatigue Severity Scale(FSS) on the day of procedure. Exclusion criteria were: anaemia with suspected SB bleeding/Crohn’s disease, inability to complete forms, incomplete/inadequate SBCE, non-specific enteritis/other non-contributory or malignant SBCE findings. Demographics, SBCE results and recent(<3 months) Haemoglobin(Hb) were recorded. SF36 & FSS scores were compared for patients with vascular lesions, Yano Yamamoto classification 1a-4 (vascular group) and normal SBCEs(control) using Fishers Exact & t-tests as required, a p value <0.05 was considered significant. <h3>Results</h3> In all 69 patients were included, mean age 67 years(range 41–93), 31(45%) were male. SBCE was normal in 30 and 39 had vascular lesions (25(64%) angiodysplasia). The vascular group was significantly older than controls(71 vs 63, p=0.01). Recent Hb was available in 19/39(49%) vascular group and 11/30(37%) controls. Mean Hb in the vascular group was lower(8.7 vs 11.1, p< 0.004, 95%CI -4.66 to -0.95). Of note demographics and mean Hb was similar for all vascular lesions. The vascular group were more likely to have a significant FSS(>36) than controls, 32/39(82%) vs 14/30(47%), p<0.0016, OR 6.0952, 95%CI 1.970 to 18.851 respectively. FSS did not differ by lesion type. The SF36 was available for 67 patients, the vascular group reported significantly worse QoL than controls for 5/8 domains. table 1. <h3>Conclusion</h3> Patients with SB vascular lesions report significant fatigue & poor QoL. This likely reflects anaemia which is refractory to conservative management as their Hb was significantly lower than patients without SB lesions referred for similar investigations. This would support the need for specific SB intervention and/or therapy for this cohort.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it