Photocatalytic C(sp<sup>3</sup>)-H and C(sp<sup>2</sup>)-H Carboxylation of Amines with CO<sub>2</sub> Using a Sustainable Covalent Organic Framework/gC<sub>3</sub>N<sub>4</sub> Composite
Bibliographic record
Abstract
Carboxylation of amines is an important route to obtain amino acids. Herein, we have reported the synthesis and characterizations of a new COF/gC 3 N 4 composite which acted as a heterogeneous photocatalyst for the carboxylation of unprotected indoles and N-Boc-benzyl amines. We have used SnO 2 nanoparticles as the cocatalyst and CO 2 as the carbon source under visible light irradiation. This gave a range of carboxylated products both with unprotected indoles and N-Boc-benzylamines with high yield. Control experiments gave the optimum reaction conditions for this photocatalytic carboxylation. Light dependency of this reaction was confirmed by altering the intensity of light. Here, we have synthesized two different catalysts, TpBpy and Tz COF, and the gC 3 N 4 heterojunction which showed excellent photocatalytic activity. The photocatalysts, COF/gC 3 N 4, are recyclable and reusable for several cycles without a significant loss in performance. The synthesis of a drug compound Clopidogrel and drug formation unit Tirofiban is demonstrated with these photocatalytic protocols.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.005 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.004 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".