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Record W4400537937 · doi:10.1016/j.ajhg.2024.05.019

Charting a landmark-driven path forward for population genetics and ancient DNA research in Africa

2024· review· en· W4400537937 on OpenAlexafffund
Elizabeth Sawchuk, Kendra Sirak, Fredrick K. Manthi, Emmanuel Ndiema, Christine Ogola, Mary E. Prendergast, David Reich, Eva Aluvaala, George Ayodo, Lamine Badji, Nancy Bird, W. Cameron Black, Rosa Fregel, Njeri Gachihi, Victoria E. Gibbon, Agness Gidna, Steven T. Goldstein, Reem Hamad, Hisham Y. Hassan, Vanessa M. Hayes, Garrett Hellenthal, Solomon Kebede, Abdikadir Kurewa, Chapurukha M. Kusimba, Elizabeth Kyazike, Paul Lane, Scott MacEachern, Diyendo Massilani, Emma Mbua, Alan Morris, Christina Mutinda, Freda Nkirote M’Mbogori, Austin W. Reynolds, Sarah A. Tishkoff, Miguel G. Vilar, Getnet Yimer

Bibliographic record

VenueThe American Journal of Human Genetics · 2024
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicRace, Genetics, and Society
Canadian institutionsUniversity of Alberta
FundersAgencia Estatal de InvestigaciónNational Institutes of HealthNational Retail FederationMinisterio de Ciencia e InnovaciónWellcome TrustFundación CajaCanariasWenner-Gren FoundationCleveland Museum of Natural HistoryJohn Templeton FoundationEuropean Regional Development FundSocial Sciences and Humanities Research Council of CanadaNational Research FoundationHoward Hughes Medical Institute
KeywordsLandmarkPopulation geneticsGeneticsEvolutionary biologyAncient DNAPopulationPath (computing)BiologyGenealogyGeographyComputational biologyDemographyCartographyComputer scienceHistorySociology

Abstract

fetched live from OpenAlex

Population history-focused DNA and ancient DNA (aDNA) research in Africa has dramatically increased in the past decade, enabling increasingly fine-scale investigations into the continent's past. However, while international interest in human genomics research in Africa grows, major structural barriers limit the ability of African scholars to lead and engage in such research and impede local communities from partnering with researchers and benefitting from research outcomes. Because conversations about research on African people and their past are often held outside Africa and exclude African voices, an important step for African DNA and aDNA research is moving these conversations to the continent. In May 2023 we held the DNAirobi workshop in Nairobi, Kenya and here we synthesize what emerged most prominently in our discussions. We propose an ideal vision for population history-focused DNA and aDNA research in Africa in ten years' time and acknowledge that to realize this future, we need to chart a path connecting a series of "landmarks" that represent points of consensus in our discussions. These include effective communication across multiple audiences, reframed relationships and capacity building, and action toward structural changes that support science and beyond. We concluded there is no single path to creating an equitable and self-sustaining research ecosystem, but rather many possible routes linking these landmarks. Here we share our diverse perspectives as geneticists, anthropologists, archaeologists, museum curators, and educators to articulate challenges and opportunities for African DNA and aDNA research and share an initial map toward a more inclusive and equitable future.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.983
Threshold uncertainty score0.900

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.081
GPT teacher head0.399
Teacher spread0.318 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations9
Published2024
Admission routes2
Has abstractyes

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